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Actizide (Glipizide)

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Actizide is an anti-diabetic medication of the sulfonylurea class used to treat type 2 diabetes. It is used together with a diabetic diet and exercise. It is not indicated for use by itself in type 1 diabetes. It is taken by mouth. Effects generally begin within half an hour and can last for up to a day.

Other names for this medication:
Actizide, Bimode, Diabizide, Diacon, Diaglip, Dibimet, Dibizide, Glanase, Glibetic, Glicept, Glipicon, Glipicontin, Glipid, Glipimet, Glipiriv, Glipitis, Glipixor, Glipized, Glipizide, Glipmet, Glucolip, Gluconil, Glumin, Glunas, Glydal, Glylin, Glynase, Glysin, Glyson, Glytop, Glyzip, Gpzide, Libiz, Metaglez, Metglib, Swiglip, Tranase, Zidmin

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Also known as: Glipizide


Actizide (glipizide) is an oral diabetes medicine that helps control blood sugar levels by helping your pancreas produce insulin.

Actizide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Actizide is not for treating type 1 diabetes.


This section provides information on the proper use of a number of products that contain glipizide. It may not be specific to Actizide XL. Please read with care.

Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

Swallow the extended release tablet whole. Do not split, crush, or chew it.

If you are taking the extended release tablet, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For type 2 diabetes: For oral dosage form (extended-release tablets): Adults—At first, 5 milligrams (mg) once a day taken with breakfast. Your doctor may adjust your dose if needed. The dose is usually not more than 20 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 5 milligrams (mg) once a day taken at least 30 minutes before breakfast. Your doctor may adjust your dose if needed. The dose is usually not more than 40 mg per day. Children—Use and dose must be determined by your doctor.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glipizide overdose can cause life-threatening hypoglycemia.

Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).


Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Actizide are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Actizide if you are allergic to glipizide, or if you have diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you have ever had:

liver or kidney disease; chronic diarrhea, or a blockage in your intestines; or an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).

Follow your doctor's instructions about using Actizide if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby. However, you may need to stop taking Actizide for a short time just before your due date.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

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Use of the chromium radioisotope 51Cr to estimate blood loss through ingestion by Fasciola hepatica. Observations on the bionomics of filariasis vector and flies of public health importance on Hsi-Yuisland of Peng-hu Archipelago, Taiwan. Structural characterization of a glycoprotein isolated from alveoli of patients with alveolar proteinosis. 1D NMR and several 2D shift-correlated NMR pulse sequences (1H,1H-COSY, HMQC, HMBC and NOESY) were used for structure elucidation and the unambiguous 1H and 13C chemical shifts assignments. Cytotoxicity of esthetic, metallic, and nickel-free orthodontic brackets: cellular behavior and viability. Moreover, WE-1-1, WE-1-2 and WE-1-4 significantly elevated 5-HT and 5-HIAA levels only in the striatum, the degrees of increase of 5-HT and 5-HIAA levels were comparable to that of fluoxetine, which significantly enhanced the levels in all regions of animal brains. Conversely, our predictions suggest that the set of nsSNPs not currently linked to diseases contains very few strong disease associations to be discovered. Enhancing the specificity of T-cell cultures for adoptive immunotherapy of cancer. The role of antiandrogenic action in cyproterone acetate-induced morphologic and biochemical changes in human semen. As persons living with HIV experience greater longevity and healthcare reform expands coverage to these high-risk populations, greater demands will be placed on the HIV-care workforce.

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Ninety-one percent of the felids evaluated had tertiary follicles, and no differences were noted between contracepted and uncontracepted cats. This individual credits his mother with directing him toward a successful heterosexual life, which he feels has prevented the emotional burden of an active homosexual life. The accuracy of diagnosis of metastatic lymph nodes of Term II was not higher than that of Term I. Unconditional logistic regression adjusting for age, sex, and center was conducted to investigate the environmental factors. The fracture reduction was completed by fixing the calcaneal tuberosity with an Ilizarov external fixation frame and distraction. Ministries of Health and stakeholders are poorly engaged in developing public health research, with the Horizon 2020 research programme, or the Structural Funds.

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As distinct from previous calculations, for nucleotides the interaction with neighbours is taken into account up to gradient of convergence equaling 1. The present community-based cross-sectional study was aimed to examine the association of metabolic syndrome (MS) with obesity measures, metabolic profiles, and intake of dietary fatty acids in Asian Indian population. This paper describes a new test designed in subcritical fluid chromatography (SFC) to compare the commercial C18 stationary phase properties. There has been a distinct slowing in the growth of discretionary noninvasive diagnostic imaging in the Medicare fee-for-service population since 2005. In addition, we intended to clarify the reasons for previously reported similar in vitro-in vivo correlations between endothelial and epithelial cell models and to evaluate whether BBMEC can provide additional value. Satisfactions, dissatisfactions, and causes of stress in medical practice.

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In a pre-post comparison, changes in mental health care consumption were examined. Animal and volunteer studies indicate that ropivacaine is associated with less neurologic and cardiac toxicity than bupivacaine. Perceived practice patterns for re-LT are at variance with published outcome data. Comparison of vancomycin-based stationary phases with different chiral selector coverage for enantioselective separation of selected drugs in high-performance liquid chromatography. Refractory status epilepticus (RSE) is characterized by a prolonged seizure that persists despite adequate initial management. STAT3-controlled transcriptional activation with yet unknown cell-specific functional consequences seems to be involved in this process. A possible biophysical mechanism of the solar activity effect on the central nervous system in man. This mnemonic advantage for bizarre sentences did not extend to memory for source (spatial location), which did not reliably vary as a function of bizarreness. Employing intramolecular bioluminescence resonance energy transfer, which can monitor conformational changes both in vitro and in intact cells, we show that binding of cGMP and sildenafil to PDE5 results in distinct conformations of the protein.

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Isozyme variation and species relationships in the genus Lolium L. Ultrasonography and CT correlated well with regard to anatomical information, especially in the assessment of the lateral and third ventricles. Laparoscopic exploration revealed a full-thickness tear into the sigmoid mesentery, which was primarily repaired using robotic-assisted technique. Studies on pulmonary function in relation to dynamic constitution. Clinical neuropsychiatric symptoms in perpetrators of severe crimes against persons. To investigate the characteristics and criterion of graft rejection in mice model. Supplements of keto acids in patients with chronic renal failure--more than modulators of nitrogen economy.

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The third to sixth codons of ndx3, a Nudix hydrolase gene from Thermus thermophilus HB8, were engineered by introducing several silent mutations. Whilst there has been some work done on the short-term postoperative recovery comparison for hand-assisted laparoscopic nephrectomy (HALN) and retroperitoneoscopic nephrectomy (RPN), to our knowledge, this is the first study to look at long-term health outcomes for these two procedures. Mutational analysis of the BRAF gene in human congenital and dysplastic melanocytic naevi. Caspase-specific and nonspecific in vivo protein processing during Fas-induced apoptosis. To facilitate matching of video images to the geometry extracted from 3D tomographic data, this paper presents a new pq-space-based 2D/3D registration method for camera pose estimation in bronchoscope tracking. Specimens from cattle and sheep suspected of having cerebrocortical necrosis (CCN) were studied.

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The first anticalins were selected to bind to small ligands, such as the cardioactive drug digoxin. Male Lewis rats weighing 150-250 g underwent a procedure designed to mimic the injury of renal transplant, in which the left kidney was perfused with cold University of Wisconsin solution and subjected to similar cold and warm ischemic times as Lewis isograft rats undergoing renal transplanation. Messenger RNAs for type I and II collagens were identified by hybridization using cDNA clones for chicken pro alpha 1(I)-, pro alpha 2(I)- and pro alpha 1(II)collagen mRNAs and by analysis of cell-free translation products of these RNAs by polyacrylamide gel electrophoresis. One preoperative and two postoperative assessments for the level of obsessionality were done with the Crown-Crisp Experiential Index (CCEI)-instrument. Accessibility to both sites is blocked in unphosphorylated p65 through an intramolecular masking of the N terminus by the C-terminal region of p65. To measure the prevalence of substance use among patients admitted to a Swiss psychiatric hospital and to examine the potential utility of routine urine drug screening in this setting. coli strains but disproportionately consisted of bovine isolates. The profile of sabcomeline (SB-202026), a functionally selective M1 receptor partial agonist, in the marmoset.

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The utility of evolutionary psychology for generating novel, specific, and a priori hypotheses about psychopathology in a parsimonious fashion: reply to Hankin (2013). The first studied isolated plants to assess the potential development of different shoot types and growth periods. Treatable bacterial infections are underrecognized causes of fever in Ethiopian children. The patient was a 65-year-old woman who presented with a recurrent thoracic meningioma status post three attempted resections, radiation therapy, and a trial of hydroxyurea chemotherapy. In contrast, estrogen injection resulted in moderate but uniform SPP1 mRNA in all LE of Day 15 nonpregnant gilts, with expression maintained through Day 90 of pseudopregnancy. Epidemiological evidence suggests that lycopene is potentially cardio-protective. The effects of pollutants from textile wastewater on the anatomy of the plant were studied.

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The effects of the energy barriers for detaching the masking domain and the ligand from the binding domain, as well as the effects of the properties of the polypeptide chain connecting the contiguous domains, are also studied. Children with developmental disorders and epilepsy have higher AAs to several neural antigens compared to controls. The final diagnosis as a gold standard relied on either pathological or post-operative findings. The cytology, histology and electron microscopy of a tumor which developed in a 16 year old male suffering from tuberose sclerosis are presented and the findings are discussed. Foot-and-mouth disease virus (FMDV) initiates infection by binding to integrin receptors via an Arg-Gly-Asp (RGD) sequence found in the G-H loop of the structural protein VP1. Surgical treatment of cerebrovascular insufficiency--a follow-up study. Immunolocalization of foreign gene expression within cells confirmed an even distribution of gene product throughout the cell cytoplasm. Anticoagulation in chinese patients with carbomedics mechanical prosthetic heart valves. Our results biaxin 250 mg are consistent with comparable clinical experience, in that infrared contact coagulation is extremely useful in surgery of the spleen.

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Determining anatomical position of the umbilicus in Iranian girls, and providing quantitative indices and formula to determine neo-umbilicus during abdominoplasty. This paper presents the first outcomes of a combined therapy of advanced cancer of pancreas with Interferon alpha, Tumor Necrosis and 5-Fluorouracil. Relative resistance of macrophage elastolytic activity to serum and alveolar proteinase inhibitors. Measurements were made at normothermia (37 degrees C), moderate hypothermia (33 degrees C), and profound hypothermia (22 degrees C) after stimulating samples with adenosine diphosphate (ADP), collagen, or thrombin receptor activating peptide. Genetic control of nucleotide excision repair (NER) in mammalian cells is well studied, but little is known about molecular mechanisms of postreplication repair (PRR) which allows bypass of base lesions in template strands after DNA replication. Production system and storage temperature influence grapefruit vitamin C, limonoids, and carotenoids. In both cases, the major contribution to catalysis was the lowering of the activation entropy. 203 Plasma samples from the umbilical vein were tested for their inhibitory activity in coagulation. Evaluation of four microkeratome models: quality and reproducibility of cut edge and cut surface as determined by scanning electron microscopy.

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We find that quasicrystals with 5-, 8-, 10-, and 12-fold rotational axes can be induced with lower laser intensities than quasicrystals with other non-crystallographic rotational symmetries. The prevalence of suicidal thoughts and plans at this age, and the inter-relationships between suicidal thoughts, plans and self-harm remain largely unexplored. We found that c-Myc remodels the organization of telomeres and chromosomes in the interphase nucleus. We applied a next-generation sequencing approach to identify the gene responsible for this phenotype in two consanguineous families. The 2,886,836 bp long genome with its four large plasmids of lengths 97 kbp, 132 kbp, 196 kbp and 315 kbp harbors 2,741 protein-coding and 58 RNA genes and is a part of the Genomic Encyclopedia of Bacteria and Archaea project. Other new developments, including combination of solenoidal coil capillary flow-probes with microflow HPLC, are also discussed. The efficacy measure was the acetylcholine induced change in mean arterial diameter, determined in the dilated segment and in an angiographically normal segment of an adjacent non-manipulated lanoxin generic name coronary artery. This shows that HMIS usage and health workers/staffs acceptance level are key tools in the success of HMIS.

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A possible mechanism for this effect could be that both HP and EP extracts display a direct dopaminergic activity, although an involvement of the GABA-ergic system cannot be excluded. Ligand amplification in a dynamic combinatorial glycopeptide library. To examine 3 types of pathogens in dead fetus with congenital defects for exploring the pathogenesis. Acute and chronic neutral endopeptidase inhibition and the natriuretic response to acute volume expansion. The authors utilized a multi-scale edge extraction method to extract feature information of nearinfrared spectroscopy. The authors also describe the characteristic psychopathological symptomatology manifested in peculiar schizophreniform disorders. Genetic and epigenetic alterations are the two key mechanisms in the development of hepatocellular carcinoma (HCC). Most of these extremities have already suffered closed blunt trauma, and many are associated with an underlying fracture. Before the apnoea test, the lungs were ventilated with pure oxygen for 20 minutes.

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Role of cationic group structure in membrane binding and disruption by amphiphilic copolymers. Although it is a benign lesion that is eminently resectable, it is a dramatic entity owing to its tendency to cause bizarre complications such as asphyxia and sudden death when it regurgitates into the pharynx and causes laryngeal impaction. Twelve single early responders (SER) were also studied in an open fashion design. This study was designed to evaluate the efficacy of an OTC remeron generic product, GelStat Migraine, when taken in the early, mild pain phase of migraine. Castration reduced the sizes of these tissues in animals of all genotypes. To compare the efficacy and safety of the electromagnetic lithotripter in the treatment of pediatric lithiasis to that of the earlier electrohydraulic model. Modern papers identifying themselves as using this approach first appeared in the 1990s, and have greatly increased up to the present. Clinical significance and potential of hepatic microRNA-122 expression in hepatitis C. The patients were tested while they were unmedicated and again following clinical stabilization.

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IL-1RI and IL-1RII mRNA levels were upregulated in vitro by various mediators, including dexamethasone, rBoIL-4, rBoGM-CSF, and rHuTNF alpha. Pain intensity, nausea, sedation, and some vital parameters were documented before the start, after each application and at the end of titration. A case study of elemental and structural composition of dental calculus is flonase nasal spray a prescription drug during several stages of maturation using SRXRF. D1 is absent from the human brain, suggesting that D2 and D3 are the two main enzymes involved in the maintenance of thyroid hormone homeostasis in the central nervous system, D2 as the primary T(3)-producing enzyme, and D3 as the primary inactivating enzyme. Addressing drug effects on cut point determination for an anti-drug antibody assay. Laparoscopic adrenalectomy has become the gold-standard for the surgical treatment of most adrenal lesions. This method enabled the better visualization of the medial circumflex femoral arterial system than the conventional femoral or internal iliac arteriography. Numerical solution of the chemical master equation uniqueness and stability of the stationary distribution for chemical networks, and mRNA bursting in a gene network with negative feedback regulation.

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In selected patients with coronary artery stenosis, the detection of vulnerable plaques with a catheter-based test followed by their treatment with a drug-eluting stent could be a less expensive and more effective strategy than current practice. The important role of both sensory and motor vagus nerves, and the available nature of peripheral vagal afferent and efferent nerve terminals, provides extensive and readily accessible targets for the development of drugs to combat nausea and vomiting. In order to document the role of this enzyme in adult rats we developed an experimental model that inhibited this enzyme using the specific inhibitor, reverse T3 (rT3). The glyburide maximum dose per day interprotein interaction was found to be attractive in solution conditions that yielded crystals and repulsive in the noncrystallizing solution conditions. The results demonstrated that the regression equation devised by the aforementioned authors for an Italian male sample was less accurate when applied to the Spanish population sample. Metabolism of 2(R,S)-1,2-bis(nicotinamido)propane, a new agent with anti-vasospasm activity, in rats and rabbits.

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Diet and expression of estrogen alpha and progesterone receptors in malignant mammary tissue. In addition, the non-opioid fragment of dynorphin, dynorphin A (2-17), is effective in potentiating NMDA currents, while the specific kappa-opioid, U50,488, cannot mimic the action of dynorphin A (1-17). In the baculovirus/Sf9 system, homogeneous, crystallizable, and nonglycosylated protein was expressed after mutagenizing three asparagines (the glycosylation sites) to glutamates. Increased spontaneous locomotor activity in the fiddler crab, Uca pugilator, after exposure to a sublethal concentration of DDT. Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38. Sporting activity is an important part of quality of life in the age group from 20 to 40 years. Nurses placing IVs did report several benefits to use of the device with specific patient groups, and future research should be conducted to demonstrate the role of the device in these patients. This paper addresses the notion that son preference hinders fertility decline, and examines the effects of patriarchal relations and modernization on fertility using the 1991 Korea National Fertility and Family Health Survey. Partial bilateral atrophy of the optic nerve in profuse gastric hemorrhage.

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