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Actocard (Metoprolol)

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Actocard is a beta-blocker used in the treatment of hypertension and angina, and used to reduce mortality due to myocardial infarction. Actocard is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.

Other names for this medication:
Actiblok, Actocard, Asoprol, Betaloc, Betaone, Blumeta, Cadmet, Dutoprol, Intramet, Macsart, Mepol, Metapro, Metin, Metocare, Metofin, Metolar, Metolex, Metomac, Metoprolol, Metozest, Metpure, Metscore, Metzok, Nexovas, Powermet, Sitelol, Supermet, Telidin, Teliprolol, Toprol, Translol, Vasomet, Vinicor, Vivalol

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Also known as: Metoprolol


Actocard is a perfect remedy. Its target is to struggle against high blood pressure. It also can be used in the treatment of chest pain, heart attacks. Actocard acts by slowing the heart rate and relaxing the blood vessels. It is beta blocker. Actocard is also known as Toprol-XL, Metoprolol, Protomet, Lopresor, Lopresar. Generic name of Actocard is Metoprolol Tartrate. Brand names of Actocard are Toprol-XL, Actocard.


This section provides information on the proper use of a number of products that contain metoprolol. It may not be specific to Actocard. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Your dose may need to be changed several times in order to find out what works best for you.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of food you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should first check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many patients feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, strokes, or kidney disease.

Swallow the extended-release capsule and tablet whole. Do not crush, break, or chew them.

If you cannot swallow the extended-release capsule:

You may open it and sprinkle the contents over a small amount (teaspoonful) of soft food (including applesauce, pudding, or yogurt). Swallow the mixture within 60 minutes. Do not store for later use. You may also use a nasogastric tube to give the medicine. Mix the contents of the opened capsule with water into a syringe. Gently shake the mixture for about 10 seconds, then flush it through the tube. Rinse the tube with water until all of the medicine is washed out.

Take the tablet or extended-release tablet with a meal or just after you eat. You may break the extended-release tablet into two pieces, but swallow the two pieces whole and do not crush or chew them.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For acute heart attack or heart failure: For oral dosage form (extended-release capsules): Adults—At first, 25 milligrams (mg) once a day for 2 weeks. Your doctor may adjust your dose as needed. However, the dose is usually not more than 200 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 25 milligrams (mg) once a day for 2 weeks. In patients with severe heart failure, the starting dose is 12.5 mg once a day. Your doctor may adjust your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 50 milligrams (mg) every 6 hours for 2 days. Then, 100 mg 2 times a day. The medicine will be started in the hospital. Children—Use and dose must be determined by your doctor. For chest pain: For oral dosage form (extended-release capsules): Adults—At first, 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 100 milligrams (mg) per day, given in two divided doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children—Use and dose must be determined by your doctor. For high blood pressure: For oral dosage form (extended-release capsules): Adults—At first, 25 to 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children 6 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 1 milligram (mg) per kilogram (kg) of body weight once a day. The first dose should not be more than 50 mg once a day. Your doctor may adjust your dose as needed. Children younger than 6 years of age—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 25 to 100 milligrams (mg) once a day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children 6 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 1 milligram (mg) per kilogram (kg) of body weight per day, given as a single dose. The first dose should not be more than 50 mg per day. Children younger than 6 years of age—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults—At first, 100 milligrams (mg) per day, given as a single dose or in divided doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 450 mg per day. Children—Use and dose must be determined by your doctor. .


If you overdose Actocard and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Actocard overdosage: fainting, difficulty, breathing or swallowing, swelling of the hands, feet, ankles, or lower legs, lightheadedness.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Actocard dosage information

Side effects

The most common side effects associated with Actocard are:

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In this review, we focus on the studies integrating micro/nano-fabrication work to elucidate the molecular mechanism of signaling transduction in cell biology. Idiopathic membranous glomerulonephritis associated with primary antiphospholipid syndrome. The receptors can be classified broadly into four groups, based on the homology of their Ig-like domains and gene architecture. Four groups of 12 Wistar SPF rats of both sexes were fed diets containing 4-bromophenyl chloromethyl sulfone (BCS) at the levels of 0, 20, 100 or 500 ppm for 13 weeks to evaluate the subacute toxicity. Characterisation of conserved non-coding sequences in vertebrate genomes using bioinformatics, statistics and functional studies. Tyrosine loading in patients with hepatic cirrhosis: lack of effect on plasma catecholamines. The immunological capacity of a single variable region to induce neutralizing antibodies in vaccinated and infected macaques initiate new ideas for a successful vaccine strategy. Arthroscopic findings in the knees of preadolescent children: report of 23 cases. The resolving power of the CCD chip is much improved compared to conventional cameras or charge-coupled devices.

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This article demonstrates a hierarchy of risk based on the intensity of the treatment setting. The analysis suggested a network of coupled fluctuations of eight rigid structural units and seven hinges that may control the transition between the active and inactive states of the channel. Bulk production and comparison of promastigote and amastigote antigens of Leishmania donovani for serodiagnosis and value of serum protein and immunoglobulin changes in diagnosis of kala-azar cases. Restriction endonuclease analysis (REA) of genomic DNA can discriminate between many Leptospira interrogans serovars. Diverse soft bottoms are also likely to be more productive in the long run, as species-specific traits (subsurface feeding) preserve fresh phytodetritus by burying it to depths in the sediment at which the mineralization rate is low. To assess the nasalance/nasality relationship and Nasometer test sensitivity and specificity when nasality ratings are obtained with both equal appearing interval (EAI) and direct magnitude estimation (DME) scaling procedures. We combine these observations with ultrastructural analysis performed by electron microscopy of the same eggs fixed at chosen stages. Such efforts should be coupled to systematic analysis of errors that occur. Abnormalities in expression of human retinal mRNA in retinitis pigmentosa.

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Drugs of abuse, such as psychostimulants and opiates, are generally considered as exerting their locomotor and rewarding effects through an increased dopaminergic transmission in the nucleus accumbens. Modifications of lipid structure and their influence on mesomorphism in model membranes: the influence of hydrocarbon chains. We examined the immunomodulatory effect of Eriobotrya japonica seed extract (ESE) on rat allergic dermatitis elicited by repeated dinitrofluorobenzene (DNFB) application on the ear. The second group, with association with vestibulocochlear dysplasias, was comprised of: one patient with moderate bilateral mixed hearing loss in branchio-oto-renal syndrome, one with profound unilateral SNHL with recurrent meningitis, and another with profound bilateral SNHL with congenital hypothyroidism. TNF-alpha has been shown to be associated with macrophage cell membranes in such a way as to retain cytolytic activity despite fixation of the macrophage effector cells with paraformaldehyde. In 2001, the ARIA guidelines were published to assist healthcare practitioners in managing allergic rhinitis (AR) according to the best evidence. Healthier times?: revisiting Indigenous Australian health history. However, ruptures of extensors and several flexor tendons were also encountered.

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Comparison of various methods for the rapid diagnosis of hydrocarbonate malabsorption. The autoclaved material forms substantial amounts of the coacervate during the digestion. On the other hand a decreased activity of these enzymes was found in organ cultures of tumors induced by methylcholanthren, following application of vinblastin and 5-fluorurazil. In the whole group analysis the scores of the fatigue scales were not altered by tDCS. Nonsteroidal antiinflammatory drugs can cause regression of adenomas, but whether they can prevent adenomas is unknown. Thoracic chordoma in a patient with paraparesis and ivory vertebral body. Population groups in Germany, The Netherlands, and the UK shared a fatty acid pattern of relatively high intakes of PUFA and SFA and relatively low intakes of MUFA, in combination with a relatively high intake of sugar. The inhibitory effect of ZSTK474 on OC formation was determined and compared with other PI3-K inhibitors by counting tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells after culturing murine bone marrow monocytic OC precursors, and RAW264.7 cells. The research findings illustrate the unique influence that the rural context has on the practice of OTs and PTs in BC. At various intervals throughout the session participants provided estimates of their blood alcohol concentration (BAC) along with breath samples for objective determination of their BAC.

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Acute SS-induced pronounced cortical cytoskeletal rearrangement characterized by myosin light chain kinase (MLCK)- and Rho-associated kinase (RhoK)-dependent accumulation of diphosphorylated regulatory myosin light chains (MLC) in the cortical actin ring, junctional protein tyrosine phosphorylation, and transient peripheral translocation of cortactin, an actin-binding protein involved in the regulation of actin polymerization. New substrates of the multispecific bile acid transporter in liver cells: interference of some linear renin inhibiting peptides with transport protein(s) for bile acids. Stimulating action of radiophosphorus on the development of the osseous callus in experimental fractures in rabbits. Culture, gram stain, catalase, coagulase test and antimicrobial susceptibility pattern were done according to clinical manual of microbiology. Heart surgery with extracorporeal circulation in long-term hemodialysis patients. We also discuss recent work on the use of natural abundance levels of (15)N to infer N sources for plants.

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Self-administered questionnaires were completed by 891 black and 11,909 white farmers licensed to apply restricted pesticides. Technique and results of electrospinograms in ten normal dogs are reported. Gestational age assessment by the examination of the anterior vascular capsule of the lens. Small bowel obstruction in early pregnancy should be diagnosed expeditiously and can be treated with jejunotomy and total parenteral nutrition. Report of a case, features by conventional and electron microscopy, and a review of relevant literature. The results of the development of methods and devices based on the effect of surface ionization (SI) and intended for the selective and sensitive registration and identification of the organic nitrogen base molecules in air and in mixtures of compounds for their chromatographic, ion mobility and mass-spectrometric analysis are presented. Methods of geometrical optics are used in deriving a simple expression for the focus error signal in terms of the parameters of an astigmatic system. Clinical significance in dementia research: a review of the literature. In agreement with previous biochemical studies, the tyrosine-sulfated protein of Mr 86,000/84,000 was found to be secretory, as it was observed in the matrix of secretory granules by immunoelectron microscopy.

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Neurologic and gastrointestinal dysfunction in cardio-facio-cutaneous syndrome: identification of a severe phenotype. Team care: ethambutol hcl 400 mg an analysis of verbal behavior during patient rounds in a rehabilitation hospital. Wound problems occurred in 2 of the patients from the culture-positive group and 4 of the patients from the culture-negative group. The survey was mailed to all US family medicine predoctoral directors. Adolescents in the alcohol-positive, high-ADI group reported significantly more substance use, peer substance use, and peer tolerance of substance use than adolescents in the alcohol-positive, low-ADI group followed by adolescents in the alcohol-negative group. The column temperature was 30 degrees C and the UV detection wavelength was 215 nm.

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(subgenus Notochaeta ) is reported, from the Serra da Pedra Branca, Minas Gerais, in southeastern Brazil. Sorafenib is the only drug that has shown a survival benefit in patients with hepatocellular carcinoma in randomized Phase 3 trials. Thymidylate synthase and dihydropyrimidine dehydrogenase activity in a metastatic liver tumor from colorectal cancer. The differential diagnosis of periorbital edema is discussed with special attention to cutis laxa, angio-edema, and blepharochalasis. IL-6 was also found to enhance the long term non-specific cytotoxicity against an allogeneic nonrenal tumor target.

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The response was peculiar to PBMC as it was not found in other cells in which IFN can normally be induced by free virions. Disturbances of gas metabolism in patients with occlusive cerebrovascular disease. coli tyrosine and yeast leucine tRNAs, which are both members of the uncommon type II class of tRNA structures. Anatomically corrected malposition of the great arteries with tubular hypoplasia of the aortic arch: a case report of surgical correction. Soil cultivation as a method for restoration of taxonomic traits of actinomyces. In the present study we evaluated the extent to which self-esteem may be an important determinant of attributional style.

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Then as now, hospital libraries reflect the institutions within which they operate. The Lumbricus preparation is cheap in price, easy to preserve, can be used in promoting wound bystolic usual dose healing, without any toxic and side-effects. For over half a century, health care providers have been faced with this problem. During a 3-hour lipid infusion, serum triglycerides reached a steady state with both emulsions in the healthy controls, whereas in diabetic patients, steady state triglyceride levels were seen only with MCT/LCT. Segment alpha 182-198 of Torpedo californica acetylcholine receptor contains second toxin-binding region and binds anti-receptor antibodies.

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Magnetic resonance images (MRI) suggested cavernous angioma as the underlying pathology. Effects of chronic administration of perfluorooctanoic acid on fatty acid metabolism in rat liver: relationship among stearoyl-coenzyme A desaturase, 1-acylglycerophosphocholine acyltransferase, and acyl composition of microsomal phosphatidylcholine. Emergency decompressive surgery was performed and the patient fully recovered. Actions of substance P on central neurones and peripheral tissues, and co-existence of 5-hydroxytryptamine and a substance p-like peptide in the heart of the snail Helix aspersa. Validation of two-dimensional echocardiography for quantifying left ventricular aneurysm: comparison with magnetic resonance imaging and evaluation during cardiac surgery. Less well documented is the possibility that increased excitability and seizures may be due to direct neuronal activation of limbic circuits, although such a mechanism would be quite plausible. Fecal consistency was inversely correlated with crypt water absorption, which was reduced in affected dogs.

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2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. Effect of gentamycin on plasma digoxin concentrations in the rabbit. No saturation of sorbitol transport could be found up to an extracellular sorbitol concentration of 80 mmol/L. In conclusion, intracisternally administered endothelin-1 modulates cardiorespiratory control by the central nervous system. Retrogradely labeled neurons were found evenly distributed on both sides in the dorsal motor nucleus of the vagus. We sought to determine whether the routine early administration of high-dose magnesium would benefit moderate to severely ill children with acute asthma.

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The ac nonlinear dielectric response chi3(omega,T) of glycerol was measured close to its glass transition temperature T(g) to investigate the prediction that supercooled liquids respond in an increasingly nonlinear way as the dynamics slows down (as spin glasses do). baschanti are consistent with those found in the two previously studied species, except for lower levels of expression at some of these sites. The Fanconi anemia cell line HSC536N is not sensitive to interferon-gamma and does not cleave PARP in response to FAS-mediated cell killing. Extensive superficial cutaneous necrosis during treatment by anticoagulants. In all groups metyrapone significantly enhanced locomotion elicited by amphetamine, probably due to a pharmacokinetic interaction between these drugs. The terminal noncancer patients had higher risks for short hospice stay, sepsis, nontraumatic shock, and respiratory and heart problems than the cancer subjects. Despite international notification requirements, the magnitude of disease transmission on board ships remains undetermined. Pharmacokinetics of dexrazoxane in subjects with impaired kidney function. The fine perylene particles were rectangular or hexagonal plates about 50nm thick. Of these 52 studies, 19 reported the costs associated with the initial period of hospitalisation, 35 reported costs incurred following the initial hospital discharge (without providing costs for the entire remaining period of childhood), four of which also reported costs associated with the initial period of hospitalisation, while two reported costs incurred throughout childhood.

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Ring chromosome 9 in a newborn: Ring chromosome 9 is a rare genetic disorder observed in the children with variable clinical presentation and phenotype. It has been demonstrated that mesenchymal stem cells are present in the adipose tissue (thus accelerating the effect of the PRP). The effect of water absorption is important for the physical properties but the mechanical changes caused by physical aging are still present after immersion in water. The loss of threshold showed a large inter-individual variability, with a rapid increase above a hypothetic threshold dose. Oversuppression of bone turnover with BPs may paradoxically limit the reserve capacity of bone to heal. The realization that tumor cells utilize multiple mechanisms to escape from immune recognition and destruction has stimulated interest in developing and applying immunotherapeutic strategies which target both humoral and cellular immunity to malignant cells. In this follow-up study, the shipboard diffuser system was replaced by a single Venturi-type injection system designed to deliver a more homogeneous biocide distribution. Biomaterial scaffolds serve to house and direct cells to grow, exposing them to an adequate perfusion of nutrients, oxygen, metabolic products, and appropriate growth factors to enhance their differentiation and function. This study was designed to test the relative effectiveness of cognitive-behavioural therapy, anxiety management training and treatment by benzodiazepines against a waiting list control.

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Reversible zovirax pill side effects impairment of endothelium-dependent relaxation in golden hamster carotid arteries during hibernation. There is continuing interest in the development of new medications, but because effective antidepressants are already available, ethical concerns have been raised about the need for placebo groups in new trials. HLA-DQ RFLP variants of five HLA-DQw2-bearing major histocompatibility complex extended haplotypes. For a more detailed analysis, a targeted proteome analysis was applied focusing on 15 proteins from respiratory, ROS-scavenging and quality control pathways. Intravenous thrombolysis is unsafe in stroke due to infective endocarditis. Sinonasal mucosal malignant melanoma: report of an unusual case mimicking schwannoma. This approach may, however, result in severely over- or under-estimated sample sizes. All sera positive for pre-S1 proteins were also positive for hepatitis B virus DNA indicating the presence of hepatitis B virions, and 16 of these sera were also positive for HBeAg.

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MutS initiates repair by binding to the mismatch, and activates together with MutL the MutH endonuclease, which incises at hemimethylated dam sites and thereby mediates strand discrimination. Arsenic contents in the urine, nail and hair in the exposed group were 24.45 microg/l, 12.58 and 6.97 microg/g, respectively which were significantly high in comparison to corresponding control group values of 4.88 microg/l, 0.51 and 0.34 microg/g, respectively. Skin-targeted therapies that lead to a resolution of the lesions of cutaneous mastocytosis are psoralen-photochemotherapy and topical corticosteroid therapy either by occlusion or intralesional injection for a limited number of lesions. Although hyperdynamic therapy is an accepted method of treatment of patients with symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage, it remains unproven in large scale trials and controlled studies. If nogalamycin was added immediately after activation of dormant spores, neither pLK229 nor pLK109 mRNA decayed, but pLK125 mRNA did decay. As the number of cognitively impaired elderly persons increases, the need for evidence-based assessments of their capacity to consent to medical treatment and research participation will grow. Johnson grass appeared to share allergenicity with both the northern grasses and Bermuda grass. However, from a public health perspective, a ban on the sale of nicotine-containing combustion tobacco products may represent the most straightforward means to minimize the harm caused by tobacco use.

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