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Acupain (Tramadol)

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Acupain is a strong painkiller used to treat moderate to severe pain. It is generally used when non-opioid painkillers don't work as well to control the pain anymore. Acupain may cause drowsiness. You shouldn't drive or use heavy machinery or perform dangerous activities until you know how this drug affects you.

Other names for this medication:
Anazac, Antram, Armadol, Arodol, Avdol, Axedol, Bludol, Bramadol, Cadol, Cemadol, Cosdol, Damol, Didol, Doleira, Dolomed, Dolstar, Domaspas, Ibudol, Jpdol, Meridol, Mobiya, Neutram, Nopidol, Opidol, Pacadon, Relidol, Tolydol, Tradol, Tramacip, Tramafen, Tramazol, Tramdop, Tranat, Trandy, Trasic, Tridol, Tromar, Ubitdol, Ultracon, Urgendol, Urogendo, Xidol, Zotadol, Zytram

Similar Products:
Norvasc, Plaquenil, Revia, Soma, Zudena, Arava, Levaquin, Ritosin, Metazol, Hyperchol, Caverject, Pironex,

Also known as: Tramadol


Acupain ER is an pain medicine similar to an opioid. This medicine is used to treat moderate to severe pain.

The extended-release form of tramadol is for around-the-clock treatment of pain. This form of tramadol is not for use on an as-needed basis for pain.


Usual Adult Dose for Pain:

Adults (17 years or older): 50 to 100 mg orally every 4 to 6 hours as needed for pain -For patients not requiring rapid onset of analgesic effect: Initial dose: 25 mg orally once a day; titrate in 25 mg increments every 3 days to reach a dose of 25 mg four times a day; thereafter increase by 50 mg as tolerated every 3 days Maximum dose: 400 mg per day.

Usual Adult Dose for Chronic Pain:

Extended-Release (ER): 18 years or older (tramadol-naive): 100 mg orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day For patients CURRENTLY receiving Immediate-Release (IR) Acupain: Initial Dose: Calculate 24-hour IR requirement and initiate with a total daily ER dose rounded down to the next lowest 100 mg increment orally once a day Conversion from OTHER Opioids: Discontinue all other around the clock opioid drugs prior to initiating therapy -Initial dose: 100 mg ER orally once a day -Individually titrate in 100 mg increments every 5 days to an effective dose that minimizes adverse reactions -Maximum Dose: 300 mg/day.

Usual Geriatric Dose for Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Geriatric Dose for Chronic Pain:

Dose selection should be cautious generally starting at the low end of the dose range Over 75 years: Maximum dose of Immediate-release: 300 mg per day.

Usual Pediatric Dose for Pain:

Acupain is not recommended for use in pediatric patients 17 years or older: See Adult Dose.

Detailed Acupain dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include severe drowsiness, pinpoint pupils, slow breathing, or no breathing.

Your doctor may recommend you get naloxone (a medicine to reverse an opioid overdose) and keep it with you at all times. A person caring for you can give the naloxone if you stop breathing or don't wake up. Your caregiver must still get emergency medical help and may need to perform CPR (cardiopulmonary resuscitation) on you while waiting for help to arrive.

Anyone can buy naloxone from a pharmacy or local health department. Make sure any person caring for you knows where you keep naloxone and how to use it.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Acupain dosage information

Side effects

The most common side effects associated with Acupain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not take Acupain if you are allergic to tramadol, or if you have:

severe asthma or breathing problems; a stomach or bowel obstruction (including paralytic ileus); if you have recently used alcohol, sedatives, tranquilizers, or narcotic medications; or if you have used an MAO inhibitor in the past 14 days (such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine).

Acupain should not be given to a child younger than 12 years old. Acupain ER should not be given to anyone younger than 18 years old.

Do not give Acupain to anyone younger than 18 years old who recently had surgery to remove the tonsils or adenoids.

Seizures have occurred in some people taking Acupain. Your seizure risk may be higher if you have ever had:

a head injury, epilepsy or other seizure disorder; drug or alcohol addiction; or a metabolic disorder.

To make sure Acupain is safe for you, tell your doctor if you have ever had:

breathing problems, sleep apnea; liver or kidney disease; urination problems; problems with your gallbladder, pancreas, or thyroid; a stomach disorder; or mental illness, or suicide attempt.

If you use tramadol during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks.

Ask a doctor before using tramadol if you are breastfeeding. Tell your doctor if you notice severe drowsiness or slow breathing in the nursing baby.

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Compression to 10 MPa caused a decrease in spontaneous beating frequency and an increased twitch tension in all preparations. STAT3 involvement in the acute phase-related expression of the rat haptoglobin gene. In this paper the authors reports increased lesions of the retina with the progression of the disease and discuss the role of the ophthalmologist in early diagnosis of AIDS. My assignment was to identify the 6 most important ALS papers published in 1999 but, great to relate, there were too many excellent candidates. Taken together, these data suggest a major role for p38 MAPK in transmitting PTH signals to regulate chondrocyte differentiation.

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5-10-year follow-up of 12 patients with childhood-onset cerebral X-linked adrenoleukodystrophy shows the long-term beneficial effect of bone marrow transplantation when the procedure is done at an early stage of the disease. A rare neoplasm of the reticulo-endothelial system: reticulohistiocytoma of the epididymis. In addition, careful skeletal and muscular reconstruction of the surgical defect is necessary for a successful outcome. An efficient solid-phase strategy for the construction of chemokines. Spontaneous transitional cell carcinoma in the urinary bladder of a strain 13 guinea pig.

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Enhanced replication of HIV-1 in vivo in pigtailed macaques (Macaca nemestrina). Subjects were required to complete a 20-question cognitive examination and a ten-point satisfaction inventory. Response of cultured rat liver epithelial cell lines to tumour-promoting phorbol esters. Study of 2 cases of adenoma and reticulosarcoma of the umbilicus. In addition heterocellular gap junctional contacts were detected between oocytes and presumptive granulosa cells as early as fetal day 17, indicating that the potential for direct intercellular communication between granulosa cells and oocytes is established from the earliest contact. We describe a child with familial hypocalciuric hypercalcemia (FHH) in whom the hypercalcemia seemed to interfere with tissue healing after tympanoplasty. Symptoms in skin prick test-negative subjects were associated with personal and parental smoking habit. Diagnosis of cystic fibrosis in the kindred of an infant with CFTR-related metabolic syndrome: importance of follow-up that includes monitoring sweat chloride concentrations over time. The Wartenberg Pendulum Test has been devised for measuring spasticity at the knee, but has been shown to be unsuitable for measuring more severe spasticity. The effects of congenital tumours on their hosts were often considerable: death by generalization (malignant lymphomas), ascites (mesotheliomas) or the growth of large abdominal tumours (nephroblastomas, mixed tumours).


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Preventing traumatic complications in convulsive shock therapy by curare by A. Differential effects of kainic-acid-induced hippocampal lesions on the acquisition of the jump-box avoidance task in mice. Cryptorchid testes were biopsied at three, five and eight months and all were excised at 12 months. A similar diurnal variation in pulmonary artery diastolic pressure was seen in the groups--that is, values were low during the day and higher at night, with the maximum values between midnight and 6 am. Photochemical reduction of CO2 with ascorbate in aqueous solution using vesicles acting as photocatalysts. Previous reports have suggested that atrioventricular (AV) flow disturbances accompanying atrial myxomas mimic mitral stenosis.

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Histopathologic examination revealed marked dermal fibrosis with excessive deposition of collagen. At the Jackson Laboratory eight-cell embryos from approximately 500 strains are preserved in liquid nitrogen storage. Resting hypermetabolism observed in AIDS patients with concurrent active infections is related to the presence and severity of systemic cytokine-driven inflammatory response, which could reflect the type of secondary infection. A severe carpal fracture dislocation is described and the alternatives of management are discussed. Measurement of the activation of equine platelets by use of fluorescent-labeled annexin V, anti-human fibrinogen antibody, and anti-human thrombospondin antibody. Electrochemical nitric oxide sensors for physiological measurements. The pulmonary veins (PVs) and surrounding ostial areas frequently house focal triggers or reentrant circuits critical to the genesis of atrial fibrillation (AF). Ten control and three ketamine cymbalta dosage amounts patients required an internal laryngeal nerve block.

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One patient was postmenopausal, and another showed menstrual irregularities. Epstein-Barr virus induces the differentiation of semi-mature dendritic cells from cord blood monocytes. The present work aimed to study this issue in 14 chronic schizophrenic inpatients by comparing their symptom clusters before and after a 20-week course of clozapine treatment. It has a broad clinical spectrum with features in most organ systems. A comparison of minority and majority medical graduates in California. In a second study, rats were sacrificed 48 hrs after a series of 5 alternate-day ECS vs. A methodical approach was used to engineer both efficient and safe packaging constructs allowing the production of SIV viral core proteins. Right atrial mass related to indwelling central venous catheters in patients undergoing dialysis.

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VMA mass screening program of neuroblastoma for infants in Nagoya City, Japan. will claritin d make me fail a drug test Adult male Sprague-Dawley rat hearts were isolated and perfused using the Langendorff method. The host-parasite relationship of Fasciola hepatica in cattle was characterized by determining the effects of the parasite on the bovine complement system. Further investigation of the possible hormonal/peptidergic regulation of anal sphincter function is necessary. Thus, in old rats bladder capacity, post-void residual urine and spontaneous activity are higher, and responses to muscarinic receptor stimulation and electrical field stimulation are lower than in young rats.

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The increasing relevance of 3D methods in orthodontic diagnostics and treatment planning calls for the development of new analysis methods and the definition of three-dimensional mean values. Prenatal radiation-induced limb defects mediated by Trp53-dependent apoptosis in mice. The structure of a short fragment of the human HIV-1 membrane glycoprotein gp41 has been examined using a combination of parallel tempering molecular dynamics (PTMD) and far UV circular dichroism spectroscopy. Music reduces panic: an initial study of listening to preferred music improves male patient discomfort and anxiety during flexible cystoscopy. Here, we show that Rad17, a replication checkpoint protein, is required for the early recruitment of the MRN complex to the DSB site that is independent of MDC1 and contributes to ATM activation. Discriminating between true-positive and false-positive clinical mastitis alerts from automatic milking systems. The same applied for those PD patients with high vascular risk, in whom the cerebral circulation could be restored. Following deglycosylation of purified ASGP-R, we detected the H2b and H2c proteins in HepG2 and HuH-7 hepatoma cells, using an antibody directed against a COOH-terminal peptide common to all H2 isoforms (anti-H2-COOH) and another antibody against a 19-amino acid cytoplasmic insert found only in H2b (anti-H2-Cyto19). It was concluded that the antitussive action of both caramiphen and dextromethorphan is due to a selective effect on the cough center in the brainstem of the cat.

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Study about radiological and immunological treatment for cancer. Absorption of IgG2-reactive material from chimpanzee serum with IgG2 mAb resulted in removal of IgG4-reactive material as well. Although individuals with end-stage renal disease (ESRD) who receive maintenance dialysis often present with memory deficits, the nature of this impairment remains controversial. Studies of the in vitro protein-synthesizing system show that T2 mRNA rarely contains the CUG codon. Same-session ERCP and cholecystectomy is safe and nifedipine adalat cc 30 mg 24 hr tablet efficacious, and its routine use should be considered. Most of these ten burns occurred from heat applied for self-care of diabetes, namely, from hot tap water, a hot moist compress, or a heating pad. They may assist in complex decision making in the clinical setting. Epidemiological survey permitted the isolation of Branhamella Catarrhalis in one of the nurse who had taken care of the neonates.

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