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Adalate (Nifedipine)
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Adalate

Adalate is used to treat high blood pressure or angina (chest pain). For high blood pressure: Adalate works by relaxing and expanding the blood vessels. This makes the blood flow more easily and lowers blood pressure. Lower blood pressure reduces the strain on your heart. For angina: Adalate works by relaxing and expanding the arteries supplying the heart. This allows more blood and oxygen to reach the heart and decreases the strain on it. Your angina attacks will be less severe and less frequent if there is less strain on the heart.

Other names for this medication:
Adalate, Adefin, Bresben, Cardalin, Cardipin, Casanmil, Chronadalate, Conetrin, Cordilat, Depicor, Farmalat, Hexadilat, Hypan, Nidilat, Nifangin, Nifebene, Nifecard, Nifedate, Nifedel, Nifedipin, Nifedipina, Nifedipino, Nifedipress, Nifelat, Nifestad, Nipin, Nyefax, Ospocard, Oxcord, Xepalat

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Also known as: Nifedipine

Description

Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adalate PA 10. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Adalate and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Adalate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Adalate if you are allergic to Adalate components. Do not take Adalate if you're pregnant or you plan to have a baby, or you are a nursing mother. Adalate can harm your baby. Do not use Adalate in combination with salt substitutes or potassium supplements. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Avoid grapefruit juice during treatment with Adalate. Try to be careful using Adalate if you suffer from kidney disease, liver disease, diseases of the heart or blood vessels (sick sinus syndrome), aortic stenosis, heart failure, low blood pressure, or coronary artery disease. Do not stop taking Adalate suddenly.

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At the spatial scale, relative abundances were similar in all surface samples along an inshore-offshore transect, but they decreased with depth. We related homocysteine concentrations and cognitive performance on the Mini-Mental State Examination in 817 dementia- and stroke-free participants of the Maine-Syracuse Study, 90 of whom were classified with type 2 diabetes mellitus. Biopsies were taken and the cavity aspirated, but, despite intravenous antibiotics, he developed penile necrotizing fasciitis necessitating open cavernostomy and debridement. We report a new case surgically treated and review the eight cases previously reported. Emphasis is placed on a nursing conceptual model as the starting point to provide an intellectual context for the concept analysis. The results demonstrate that only the late blastocyst protein synthesis pattern shows most of the polypeptides identified in the differentiated protein synthesis pattern of teratocarcinoma. At the first examination after treatment all 97, including 76 to whom metronidazole had been given orally only, were found by culture and wet smear to be free of trichomonads.

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Two cases with expressed signs of a permanent muscular tension in the extremities with fasciculation (the Isaacs syndrome) and difficulties in self-service are described. In addition, histological examination revealed that application of ImmuBalance decreased the number of PGP9.5-positive neuronal fibers in the lesional skin. Surgical reconstruction for mesenteric angina in a patient with infra-renal aortic occlusive disease--a case report and review. Photonic crystal light collectors in fish retina improve vision in turbid water. A combination of mitomycin C and gemcitabine seems to improve the reduction achieved with TACE. A series of 18 histologically verified cases with negative angiography. New developments concerning alignment media for apolar solvents like chloroform make it possible to measure anisotropic parameters such as residual dipolar couplings (RDCs) at relatively low concentrations and natural isotopic abundance. The violation of these assumptions commonly results in overdispersion. The kisspeptin-GPR54 signaling system has a considerable role in GnRH physiology and induction of puberty.

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Rapid subtype identification of any AIV is of major interest because of the possible serious consequences for the poultry industry and even public health. However, recent literature suggests that overweight teens may be at increased risk for weight gain while on this contraceptive method, and decreases in bone mineral density have been documented in adolescents on DMPA, particularly with longer duration of use. Dose-response relationships between more severe psoriasis and higher prevalence of metabolic syndrome components were recently established. Socioeconomic status and obesity in Abia State, South East Nigeria. Side effects limit its benefits, but besides anticoagulant activity HEP has diffuse actions that may be potentially beneficial to jeopardized reperfused myocardium. The prospective study included 112 patients with advanced larynx cancer after radical surgical treatment.

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Effect of flutamide on the testis and accessory sex glands of the musk shrew, Suncus murinus L. The construction process and the ethical-political principles of a National Policy of Popular Education in Health are presented, discussing the participation of nursing in the changes of educational practices, in spaces of political representation and formulation of public policies, with a perspective of achieving a fair and equal social order. Senckenbergs Stiftung und die Frankfurter Republik der Aerzte im 19. These results were used to estimate the rate of TB infection by a mixture model. The objective of this work was to study the association between ghrelin and the metabolic syndrome and identify social and behavioral determinants of ghrelin.

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Use of a simulation model to study the acute haemodynamic effects of diazoxide in man. The basis for applying these principles to graded-exercise-tolerance testing is also discussed. The effect of parenteral lipid emulsions on pulmonary hemodynamics and eicosanoid metabolites in preterm infants: a pilot study. The effect of variation of electrolyte intake, acidosis and alkalosis. Rifampin induced docetaxel metabolism 6.8- to 32-fold above docetaxel metabolism in control cultures. We have shown that subcutaneous immunization with H-2D(b)-restricted HPV16 peptide was able to generate CTL-mediated cytolysis of HPV16 E6- and E7-expressing TC-1 tumor cells in vitro, as well as protect against in vivo challenge with TC-1 cells in C57BL/6 mice. It includes promotion of mental health, identification of risk factors across the life cycle, and appropriate early interventions.

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RNAi-based validation of antibodies for reverse phase protein arrays. Students living in Northern Ireland had higher death anxiety and stronger fears than students living in the Republic. This study aims to estimate bisphosphonate effectiveness by comparing fracture incidence over time on therapy with fracture incidence during a short period after starting a therapy. Many of the studies have not accounted for confounding factors such as gender, handedness, or clinical variables such as neuroleptic exposure. Leishmania braziliensis and Leishmania mexicana: experimental cutaneous infections in golden hamsters. Recent lines of nonsteroidal anti-inflammatory drugs research have focused on the development of daily topical administration forms such as gels, toothpastes, and rinses. Such ideas flourished in the colonies and in the medical services of the armed forces, but their exponents were not marginal men.

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Pump-based CNP infusions increase skeletal growth in a mouse model of the most common type of human dwarfism, which supports CNP/GC-B-based therapies for short stature diseases. Role of gamma-ray encephalography in the diagnosis of recurrent brain tumors. A dose of 10mmol/kg was sufficient to achieve plasma levels of 10 to 16mM is zyrtec r safe while breastfeeding comparable to serum levels in patients at the end of a transurethral prostatectomy. Effect of adenosine on three dimensional tube formation and angiogenesis of human umbilical vein endothelial cell (HUVEC) in vitro. These findings reveal cellular and molecular mediators of serotonergic signaling. In addition, wheat accessions from diploid (AA, SS/BB, and DD genomes), tetraploid (AABB), and hexaploid (AABBDD) Triticum species were tested for the presence of T-cell-stimulatory epitopes in gliadins and glutenins by both T-cell and monoclonal antibody-based assays.

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Four cases of osteomyelitis were found, and although debridement was not frequently done, the incidence of osteomyelitis was higher following debridement than it was without debridement. Routine use of intraoperative angiography influences outcome after embolectomy for upper-limb acute arterial occlusion. More studies are needed to clarify the mechanisms by which serum leptin level is influenced as a result of zinc supplementation in HD patients. Mitochondrial proteins were observed to be predominantly iodinated in ET but not in TT mitochondria. Serum anticonvulsant monitoring by liquid chromatography with a methanolic mobile phase. P-gp expression and functionality does not seem to change at early stage after induction of anticipated pharmacoresistant epilepsy by kainate. Using quantitative analysis method, we analysed the authors, co-authors and the core authors of papers published between 1995 to 2004.

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Breast cancer now represents the most common female malignancy in both the developing and developed world, and is the primary cause of death among women globally. In the classification based on radiological findings the numbers of infants in classes 1, 2 and 3 were 18, 19 and 18 respectively. Influence of media and temperature on gliotoxin production in Aspergillus fumigatus strains. Taking these in mind it is highly probable that there is multilevel system of regulation that is able to maintain control of signaling. Effects of x-rays on the growth, maturation and fertility in rats irradiated on the 7th day after birth. It has an excellent safety and tolerability profile, with a low propensity to cause hypoglycaemia due to its transient, selective effect on early phase insulin secretion. The remainder of the bald scalp was transplanted with 800 follicular implants placed in the traditional way. Results suggest that lower levels of education, exposure to grotesque burn injuries, stressful life events following exposure, and feelings of numbness following exposure are useful predictors of subsequent development of PTSD. Moreover, the role of FBMs on biochemical differentiation of Clara cells, type I and type II pneumocytes is reviewed.

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Further observations on a focus of human trichostrongyliasis in the Viterbo resident. This approach provides a basis for developing a picture of the ancestral mammalian karyotype, but a full understanding will depend on studies encompassing more diverse combinations of mammalian orders. Except for Ala104Val, these mutants bound less strongly to a tropomyosin affinity column and were less able to stabilize the TM overlap complex, effects that were correlated with increased stability of the troponin T, measured using circular dichroism. Understanding the temporality of mental health presentations to the emergency department (ED) during the 24-hour cycle, day of the week, and month of the year may facilitate strategic planning of ED-based mental health services. Advances in proteomic analysis of human samples are driving critical aspects of biomarker discovery and the identification of molecular glucophage metformina clorhidrato 500 mg pathways involved in disease etiology. Flow cytometric analysis of lymphocyte subsets in migraine patients during and outside of an acute headache attack.

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Plasma AVT concentration, pituitary AVT content, hypothalamic provasotocin mRNA expression and other osmoregulatory parameters were measured in euryhaline flounder 4, 8, and 24 h after the hypertonic challenge of transfer from fresh water (FW) to seawater (SW). Single 200 or 400 mg doses of lumiracoxib provided rapid and effective relief from the acute pain associated with ETTH. In this study, we propose age-specific reference ranges for LVSIsys and LVSIdia. A cost analysis of SHD and in-center hemodialysis (ICHD) from a societal perspective was performed to establish the efficiencies associated with shifting resources and patients from ICHD to SHD. In addition several new parameters were investigated: factor XII, prekallikrein, Simplastin A--another prothrombin complex factor method, factor X, plasminogen (PLG), antiplasmin (AP) and kallikrein inhibitors (KI). The SAR leading to the identification of the optimal azaindole regioisomer as well as the pharmacokinetics and off-target activities of the most potent antagonists are disclosed. Coxiella burnetii shedding and environmental contamination at lambing in two highly naturally-infected dairy sheep flocks after vaccination. The resulting boron compounds are potentially important reagents for both materials science and medical applications such as in boron neutron capture therapy (BNCT) in cancer treatment and as drug delivery agents and synthetic intermediates for carbon-carbon cross-coupling reactions.

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