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Adefin (Nifedipine)

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Adefin is used to treat high blood pressure or angina (chest pain). For high blood pressure: Adefin works by relaxing and expanding the blood vessels. This makes the blood flow more easily and lowers blood pressure. Lower blood pressure reduces the strain on your heart. For angina: Adefin works by relaxing and expanding the arteries supplying the heart. This allows more blood and oxygen to reach the heart and decreases the strain on it. Your angina attacks will be less severe and less frequent if there is less strain on the heart.

Other names for this medication:
Calchan, Calcianta, Calcibloc, Cardalin, Cardicon, Cardifen, Cardiosol, Citilat, Conetrin, Cordipin, Depicor, Depin, Fedip, Fenamon, Ficor, Hypan, Marivolon, Milfadin, Nedipin, Nifcal, Nifecap, Nifecor, Nifed, Nifedel, Nifedipino, Nifedipinum, Nifehexal, Nifelong, Nifestad, Nirena, Vasdalat

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Also known as: Nifedipine


Nifedipine is used alone or together with other medicines to treat severe chest pain (angina) or high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nifedipine is a calcium channel blocker. It works by affecting the movement of calcium into the cells of the heart and blood vessels. As a result, nifedipine relaxes blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload.

This medicine is available only with your doctor's prescription.


This section provides information on the proper use of a number of products that contain nifedipine. It may not be specific to Adefin. Please read with care.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the extended release tablet whole. Do not break, crush, or chew it. It is best to take this tablet on an empty stomach.

If you are taking the extended-release tablets, part of the tablet may pass into your stool after your body has absorbed the medicine. This is normal and nothing to worry about.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For treatment of chest pain or high blood pressure: For oral dosage form (capsules): Adults—At first, 10 milligrams (mg) three times a day. Your doctor may increase your dose as needed. Children—Use and dose must be determined by your doctor. For oral dosage form (extended-release tablets): Adults—At first, 30 or 60 milligrams (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 90 mg once a day. Children—Use and dose must be determined by your doctor.


If you overdose Adefin and you don't feel good you should visit your doctor or health care provider immediately.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Detailed Nifedipine dosage information

Side effects

The most common side effects associated with Adefin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nifedipine in the elderly. However, elderly patients are more likely to have age-related kidney, liver, or heart problems which may require caution and an adjustment in the dose for patients receiving nifedipine.

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Thromboembolic events and cardiovascular mortality in inflammatory bowel diseases: a meta-analysis of observational studies. In conversion experiments using the transglucosylation approach, the free or immobilized enzyme accepted primary and even tertiary organic alcohols, as well as primary and secondary artificial organosilicon alcohols, as aglycones. Here, we found that snake venom-derived arginine-glycine-aspartic acid (RGD)-containing disintegrin inhibited adipogenesis. These primers were inferred from genome sequence data from nine Hymenoptera (seven species of ants, the honeybee, and the parasitoid wasp Nasonia vitripennis). The objective was to evaluate possible pharmacokinetic and pharmacodynamic interactions for repeated nightly zolpidem dosing with fluoxetine. NBS1 controls both the nuclear localization of the MRN complexes and radiation-induced focus formation. Since there is a great number of genes discovered and of mutations within the same gene, and the clinical picture of different diseases can be similar, a previous study of the protein is advisable as a guide for a further genetic study. The heterogeneity represented by the standard deviation of BF is the most reliable diagnostic parameter for distinguishing between low grade and high grade lesions. Direct isolation of satellite cells for skeletal muscle regeneration. Candidemic patients were followed up for outcome and the effect of nosocomial candidemia on mortality was assessed and analyzed statistically.

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Circadian rhythm of the signal averaged electrocardiogram and its relation to heart rate variability in healthy subjects. Future research should further elucidate its pathogenesis, reveal better ways to diagnose it, and yield new treatments. MAb 2D9 reacted to the antigenic components of the luminal content and epithelial cell lining the cecum, whereas MAb 2D10 reacted specifically to the antigens of the tegument and surface membrane. Spatiotemporal variations in species diversity to assess environmental impacts on aquatic communities: The use of biomass data versus density data. This new approach could be performed safely with acceptable morbidity and mortality in selected patients treated in specialized centers. A Decree of 1377 of the Rector of Dubrovnik-Ragusa officially issued quarantine.

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Surveillance is an essential component of effective clinical programs designed to reduce the frequency of adverse events such as infection or injury. From the perspective of human factors engineering, some root causes of poor pictogram as well as their relations with medical equipment adverse events were addressed. All animals subjected to multivisceral xenotransplantation showed a progression of endoscopic lesions with time after transplantation, while animals subjected to allotransplantation showed no aberrations in endoscopy. newsami, but also that the volatile allelochemicals released from A. We report on a patient with an interstitial 6q deletion presenting with moderate mental retardation, persisting hypotonia, facial dysmorphism, but no internal malformations. These results suggest a new function of Mec1 that operates through RPA to locally control reciprocal recombination.

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We present an indentation tonometer for use in measuring the softness or firmness of human, female breasts. Most pediatricians have experienced uneasy interactions involving patients and/or their parents. These fatalities have augmented slightly in the past decade, but they are a poor recognized type of vehicle injury and little research has been done to discover the circumstances surrounding the fatal event. As a result, investigations were undertaken to assess the possible nature and extent of any potential sources of PCDDs and PCDFs on the RMA site. The responsibilities of occupational physicians are rather comparable, though in some countries the approaches of occupational medical prevention and the interest in evaluating the structure, process and outcome of many of the activities of occupational medicine seem to recede something into the background. A new graphical method of determining the kinetic constants for immobilized-enzyme systems is proposed and illustrated with some examples. This meta-analysis compared efficacy (pain response) of drugs that are licensed or commonly used in the treatment of fibromyalgia. Motor agitation developing in some white rats during painful stimulation of other individual decreases under the action of phenasepam (the most effective drug used in clinic in cases of neurotic alarm). It seems that aFGF and bFGF play an important role in transformation of normal myometrium into leiomyoma and further growth of this tumour. New direct-acting antivirals in the development for hepatitis C virus infection.

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Subsequent lung and skin biopsy revealed many granulomas consistent with sarcoidosis whereas synovium revealed changes typical for RA. We compared sequences and phylogenetic distributions of all members of the DUS family and inferred the phylogenetic tree, which provides a framework to study the functional differences among these proteins and suggests a scenario for the evolutionary origin of dihydrouridine formation. Pneumococcal neuraminidase A: an essential upper airway colonization factor for Streptococcus pneumoniae. Acute liver failure due to amoxicillin and amoxicillin/clavulanate. While a nucleocytoplasmic shuttling mechanism has been proposed for SIRT2, recent studies have indicated the presence of a constitutively nuclear isoform. Examining the power spectra of heart rate variability of recovery period(after 20 minutes microwave exposure) shows that the change of power spectra of heart rate variability signal during microwave exposure is not permanent. Outcomes of minimally invasive valve surgery versus median sternotomy in patients age 75 years or greater. Right lower quadrant pain in a patient with inflammatory bowel disease of undetermined type. The maximum suspended sediment concentration was observed at the peak of the flood hydrograph. Tobacco mosaic virus (TMV) particles are rod-like, 300 nm long and 18 nm in diameter.

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Determination of biogenic amines and endotoxin in squid, musky octopus, Norway lobster, and mussel stored at room temperature. The application of RAPD markers for the evaluation of germplasm and cocoa improvement programmes are discussed. To assess the risk of second primary cancers among women with previous breast cancer and calculate the excess burden of second cancer in the population. These results indicate that the cerebellar cortex is involved in the appearance of various grooming elements but not in the organization of the cephalocaudal sequence. Available data on helminth genetic variability have shown that most helminth populations exhibit different levels of genetic variation resulting mainly from the pattern of life cycle,geographical distribution and parasite-host interaction,and several hypotheses have been proposed to explain the genetic variation. Higher levels of activation markers and chemokine receptors on T lymphocytes in the cervix than peripheral blood of normal healthy women. Several of these cofactors have protein domains containing tetratricopeptide repeat (TPR) motifs, which mediate binding to hsp90. A study of success predictors in the entrance examination to the school medicine (2006-2008). CNP was considerably stable and stored in the organisms though the concentration in the aquarium water was relatively low.

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They covered a range of aspects relating to the use of ethnicity in the genomics project, including views on adverse effects of the inclusion of ethnicity in such research. However, in children thelorrhagia is due to benign mammary duct ectasia in the majority of cases. Stereology demonstrated weak or no correlation to pathology and urinary Kim-1. The aim of the study was to investigate cerebral circulation in systemic lupus erythematosus in the dynamics of the pathological process using MRA data. Individuals with DS have high levels of oxidative stress throughout their lifespan. Increases in vascular (Ea), ventricular systolic (Ees), and ventricular diastolic (Ed) elastance (stiffness) may contribute to the pathogenesis of heart failure (HF) with preserved ejection fraction (HFnlEF). Can jumping capacity of adult show jumping horses be predicted on the basis of submaximal free jumps at foal age?.

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Characterization of alpha thalassemic genotypes by multiplex ligation-dependent probe amplification in the Brazilian population. However, recent advances in therapies allow not only to extend treatment at advanced ages and in presence of significant comorbidities, but also to induce prolonged remissions. Poor teamwork skills are a significant cause microzide medication of adverse maternity care outcomes. Moreover, the interest of geometric transfer was investigated simultaneously in order to stress a little bit more the transfer exercise and, by the way, emphasize the additional benefit of DS strategy in this particular context. Fatigue is the most frequent and often debilitating symptom of chronic hepatitis C. Furthermore, more studies are needed to describe the epidemiology of ESRD and for assessing the overall quality of renal care.

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N-acetylcysteine protects against radiocontrast-induced nephropathy -- pro. Evolution of thrombin and other hemostatic proteases by survey of protochordate, hemichordate, and echinoderm genomes. ASThiPS lines were indistinguishable from human embryonic stem (ES) cells based on the expression of pluripotent markers and the ability to differentiate into the three embryonic germ layers in vitro by embryoid body generation and in vivo by teratoma formation after injection into immunodeficient mice. Endoscopic ultrasound-guided fine-needle aspiration in patients with non-small cell lung cancer and prior negative mediastinoscopy. Delta functions as a cell nonautonomous membrane-bound ligand that binds to Notch, a cell-autonomous receptor, during cell fate specification. adalat 20 mg An orthopedist had been sentenced for different offenses to two years and six months imprisonment by the Landgericht Frankfurt (superior court). We hypothesize that the elevated alkaline phosphatases (ALP) observed during the pregnancy demonstrate the presence of syncytiotrophoblastic lesions due to histiocytosis in the intervillous space, before fibrin deposits cover them. To further study the role of AtTCP14 and AtTCP15 in plant development, we expressed them in tomato plants. The patient underwent a sub-occipital craniotomy with gross total resection of the intra-parenchymal lesion.

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However, the extent of anterior defects is sometimes difficult to quantitate during endoanal ultrasonography. Correlations agree with the mechanisms of oxidation involving both one-electron and two-electron transfer processes to yield intermediates and products of the reactions. Palivizumab is beneficial in prophylaxis for infants at high-risk for severe RSV infection although optimal indications based on cost-effectiveness considerations have not been defined. The objectivity and simplicity of its components may allow its implementation in fetal cardiology units. This data will inform the time course of pain resolution, potential onset, and correlation with surgical weight loss. Occupational blood and body fluid exposure in an Australian teaching hospital. Factors predicting outcome in malignant minor salivary gland tumors of the oropharynx. Pathological examination revealed a subependymal giant-cell astrocytoma. Operative and pathologic data were collected, as well as pioglitazone hcl brand name details concerning the incidence, clinical features, treatment, and outcome of anastomotic leaks.

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12 out of 15 patients had documented seroconversion to anti-HCV. We introduce a young patient who had chronic pancreatitis and underwent several plastic stent insertions due to recurrent pancreatic duct stricture. We used representational difference analysis to identify candidate E2A-HLF target genes. During the hypotensive phase of electronocuous shock in rabbits, injection of nalorphine to the hypothalamus provoked elevation in the blood pressure (BP), recovery of the evoked potential (EP) of the sensorimotor brain cortex in response to electrodermal stimulation (EDS) of the hind limb. Characterization of cell death pathways in human immunodeficiency virus-associated encephalitis. The binding of biotin analogues by streptavidin: a Raman spectroscopic study. The activities of enzymes and the contents of glutathione and of pyridine. The salivary concentration of dapsone and its monoacetyl derivative reflect the protein-free, active drug in serum. Magnetic resonance imaging based and autopsy studies indicate that prilosec otc vs prescription dose early rapid increase in brain size during infancy could underlie the deficits in a large subset of subjects.

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Administration of methylprednisolone, 30 mg/kg, intramuscularly, every eight hours for three days to 26 of the 49 rabbits did not alter the rate of roentgenographic resolution of the pneumonitis. The in vitro effect of different doses of fig tree latex on stomach cancer cell line and the peripheral blood mononuclear cells was evaluated after 72 hours. Detection of expression of heat shock protein 47 mRNA in pathological scar tissue by using real-time fluorescent quantitative RT-PCR. The large coronary reserve in LIMA sequential grafts may contribute to an improved long-term patency. 30 years of patient education in the use of pessaries: personal history of Mrs. From the literature it is summarized that the normal Qmax is 20-36 ml/s. This Gap family represents a new paradigm for the transport of small molecules across the mycobacterial envelope, a critical determinant of mycobacterial virulence. To characterize the epidemiology and clinical course of children with juvenile idiopathic arthritis-associated uveitis (JIA-U) in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry and explore differences between African American (AA) and non-Hispanic white (NHW) children. We show that both forms of adaptation can be well described using different time constants for the kinetics of Ca ions (faster) and the kinetics of the feedback mechanisms (slower).

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The triangular frame provides adequate stability so that the patient can undertake independent bed-to-chair transfers and early resumption of a weight-bearing gait. Placental growth factor, pregnancy-associated plasma protein-A, soluble receptor for advanced glycation end products, extracellular newly identified receptor for receptor for advanced glycation end products binding protein and high mobility group box 1 levels in patients with acute kidney injury: a cross sectional study. Creation of a safety culture: reducing workplace tenormin 25 mg injuries in a rural hospital setting. Innovation challenges for handling supply chain risks have become one of the most important drivers in business competitiveness and differentiation. In the mouse lung, Sfta2 was significantly downregulated after induction of an inflammatory reaction by intratracheal lipopolysaccharides paralleling surfactant proteins B and C but not D. In the test phase afterwards, the monkeys made a choice of their own. In ligament tissues, BMP-2 mRNA was present in the chondrocyte-like cells in the fibrocartilage zone.

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Photoisomerizable arylstilbazolium ligands recognize parallel and antiparallel structures of G-quadruplexes. Different surgical approaches were selected depending upon different pathological changes. Antibodies against pneumococcal and haemophilus polysaccharides, and total IgG, IgG1, IgG2, and IgA concentrations were measured in 33 cardiac-transplant recipients transplanted before the age 4 years (group 1) and after that age (group 2). DNA was extracted from the vessels as well as the respective blood from each patient and subjected to polymerase chain reaction. Most of the statistical testing procedures in this area have been developed for three-arm NI trials in which a new treatment is compared with an active control in the presence of a placebo. Two dose levels of NFV were investigated: 625 mg twice daily (bid) and 1,250 mg bid in a cohort escalation design.

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