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Alendronate is used to treat osteoporosis caused by menopause, steroid use, or gonadal failure. Alendronate is for use when you have a high risk of bone fracture due to osteoporosis. Alendronate is also used to treat Paget's disease of bone.

Other names for this medication:
Alant, Alendix, Alendronate, Alenost, Bifosa, Denfos, Osteofos, Ostogee, Poronil, Ralenost, Restofos, Zophost

Similar Products:
Albenza, Daklinza, Robaxin, Nuvigil, Aldactone, Nolvadex, Lipitor, Craveril, Betam, Ativan, Norgest, Lizocas, Vermiz, Zalvon, Budesonide, Calday,


Alendronate (alendronate) is a bisphosphonate (bis FOS fo nayt) medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures.

Alendronate is used in women to treat or prevent osteoporosis caused by menopause and in men and women to treat osteoporosis caused by taking steroids.

Alendronate is also used to increase bone mass in men who have osteoporosis, and to treat Paget's disease of bone in men and women.


Take Alendronate exactly as prescribed by your doctor. Alendronate is taken either once daily or once per week. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take Alendronate first thing in the morning, at least 30 minutes before you eat or drink anything or take any other medicine. If you take this medicine only once per week, take it on the same day each week and always first thing in the morning.

Take with a full glass (6 to 8 ounces) of plain water. Do not use coffee, tea, soda, juice, or mineral water. Do not eat or drink anything other than plain water.

Do not crush, chew, or suck on an Alendronate tablet. Swallow the tablet whole.

For at least 30 minutes after taking Alendronate:

Do not lie down or recline. Do not take any other medicine including vitamins, calcium, or antacids.

Pay special attention to your dental hygiene while taking Alendronate. Brush and floss your teeth regularly. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are using alendronate.

Alendronate is only part of a complete program of treatment that may also include diet changes, exercise, bone mineral density testing, and taking calcium and vitamin supplements. Follow your doctor's instructions very closely.

Store at room temperature away from moisture and heat.

Your doctor will determine how long to treat you with this medicine. Alendronate is often given for only 3 to 5 years.

Detailed Alendronate dosage information


Drink a full glass of milk and seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Do not make yourself vomit and do not lie down.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Alendronate are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Generic Alendronate if you are allergic to Generic Alendronate components. Be very careful with Generic Alendronate if you are pregnant or planning to have a baby, or you are nursing mother. Generic Alendronate can harm a baby. Be careful with Generic Alendronate if you suffer from or have a history of low blood calcium (hypocalcemia), a vitamin D deficiency, kidney disease, an ulcer in your stomach or esophagus. Be careful with Generic Alendronate if you are taking aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Naprosyn, Aleve); cancer chemotherapy; or oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone). Do not stop take it suddenly.

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The bone bract was dislocated in the intercondylar notch in a patient submitted to Hughston surgery because of proximal disinsertion of the new ligament. The results obtained in a comprehensive experimental study on the redetermination of the structure of N(4)P(4)F(8) with single-crystal X-ray diffraction, gas electron diffraction (GED), and differential scanning calorimetry (DSC) establish clearly that, in contrast to the previous report, the eight-membered heterocycle is not planar. This article examines the evidence related to ECG screening in athletes and presents a contemporary model for primary prevention of SCD in sport. To date, the majority of published studies investigating the cause of disease variability in CF report associations between candidate genes and some aspect of the CF phenotype. However, remission status was not related to functional recovery, suggesting that the current focus on symptomatic remission may reflect an overly restricted goal.

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In contrast, single peroxynitrite administration specifically induced the MR transactivation activity whereas genomic GR activity remained unchanged. The current treatment approaches to these lesions include observation and surgical resection. Arachidonic acid strongly induced expression of Cry j 3.4 and Cry j 3.6, and weakly induced that of Cry j 3.3, whereas expression of Cry j 3.1 and Cry j 3.5 was unaffected. To prevent damage to the endothelium of the veins during operation, the heels should be elevated off the operating table by means of a small rolled towel in order to take weight off the calf muscles. Socket grafting with or without buccal augmentation with anorganic bovine bone at immediate post-extractive implants: 6-month after loading results from a multicenter randomised controlled clinical trial. The procedure is most effective in the treatment of mild and moderate stages of the disease. When differences occurred, they generally favored the brief groups.

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The purpose of this study was to undertake a computational modeling analysis of the deposition kinetics of a magnetite nanoparticle agglomerate in cell culture medium. In the present article, we report 14 cases of patients with different tumors, injured or died after a traumatic episode. Effect of chelating agents and phosphoramidon on the L-leucine transport system in microvillar vesicles from pig kidney. Shortsighted dislocations and political interference have deprofessionalized and decimated our ability to control, rather than to destroy, the governance of bureaucracy. To establish reference intervals for major haematological and biochemical parameters in Gabonese infants and children. Two cases of lactobezoar formation were seen in premature low-birth-weight infants in a 24 cal/oz formula fortified with medium-chain triglycerides and glucose polymers given by continuous nasogastric infusion.

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Effect of vitamin E supplementation on the vitamin content of lipoprotein in young men and women. The victim profile was composed of the following features: middle aged male, rural habitant, who carried out a suicidal act by consuming primarily methomyl or paraquat (WHO toxicity class Ib and class II, respectively). Retrospective analysis showed the serum levels of alphafetoprotein (AFP) are markedly elevated in both cases. Significant levels of HIV-1 are associated with platelets during all stages of infection. Clinical course of whooping cough in children younger than six months. Thyroid hormone and cardiac repair/regeneration: from Prometheus myth to reality?. This study was performed to evaluate in vivo and in vitro data on the effects of the adrenal steroid dehydroepiandrosterone (DHEA) with emphasis on its potential use in the treatment of systemic lupus erythematosus (SLE). D609, a phospholipase C inhibitor, significantly inhibited ciliary beat frequency increase and PGE2 production during methacholine stimulation. Colic has been known for many years, but I am unaware of any good remedy for it. Facts, events, and inflection: when language and memory dissociate.

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Effective primary prevention programs in public health and their applicability to the prevention of child maltreatment. Depending on the prevailing conditions, acetate can be used byR. The XLMR group is currently comprised of 105 highly varied types of retardation that can be associated with a fragile X chromosome, biochemical defect, neurologic alterations, bony dysplasia and a range of malformations. Mechanical thrombectomy is an alternative way to go: the European experience commentary on: quality improvement guidelines for percutaneous management of acute limb ischemia. Abnormal duodenal loop: influence on basal and food-stimulated motility pattern. In spite of the comprehensive multidisciplinary approach to the management of this disease, the prognosis remains dismal. The Dutch Lower Extremity Functional Scale was highly reliable, valid and responsive in individuals with hip/knee osteoarthritis: a validation study. Recently published outcomes data demonstrate feasibility, safety and reproducibility for LESS in gynaecology. The maturity of the auditory system influences ABR responses in infants. Upon designing and implementing a literature course on family values for Year 4 medical students, we found that while the supposed benefits of literary inquiry were to lead students to a deeper understanding of difficult issues such as illness and violence in the family, many of our students were unable to engage critically with the course material.

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In HP rats, PV glucose rose during fasting (0800-1700) and declined during feeding (1700-0800), changes that reflected alterations of glucagon and insulin secretion. Perfluorocarbons are now being used as oxygen carriers in clinical settings. Serum HCV RNA positivity and mean virus titer were similar between HCV carriers with or without GBV-C/HGV co-infection, and those with GBV-C/HGV co-infection seemed to have a lower serum ALT level. Presence of neurotrophic factors in skeletal muscle correlates with survival of spinal cord motor neurons. It was assumed that the sample loadability of the stationary phase is constant for a constant value of the separation factor and different mobile phase conditions and temperatures. Raman micro-spectroscopy can be used to detect HPV and differentiate among specific HPV strains.

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The following article presents information from English peer-reviewed journals identified by a Medline search covering the years from 1974 through 2004, and attempts to integrate information available in the dental literature and address current controversies and issues in selecting diameter, length, and shapes of dental implants. Long-term radiographic assessment of secondary alveolar bone grafting outcomes in patients with alveolar clefts. Pharmacological treatment to augment hole board habituation in prenatal Vitamin D-deficient rats. Because of this potential association, patients who are considered to have this anomaly should have early newborn thyroid screening. There was no evidence of important differences in feeding intolerance. The possible embryonic development of these branching patterns and their clinical significance are discussed briefly. Study on IR of interaction of three modified-starchs and crystallization of calcium carbonate. Two classes of putative pheromone receptor gene families, V1R and V2R, are expressed by vomeronasal sensory neurons in mutually segregated epithelial zones of the vomeronasal organ. Because glandular hyperplasia is a central histologic feature of CRS, the identification of overexpressed glandular genes in the sinus mucosa lays the groundwork for future studies of glandular hyperplasia, and may ultimately lead to the development of novel treatments for mucous hypersecretion in patients with CRS. This paper presents a detailed kineto-static analysis of the system and a first prototype of the device.

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Thus, we tested other hypotheses, including spatial confinement by the large central vacuole, background efflux and localised degradation, and investigated the robustness of cell specification under different parameters and assumptions. The perceptive networks and motor network were less affected by GSWD. The expression of cancer/testis antigens (CTAs) on additional normal tissues or stem cells may restrict their use as cancer targets. Coiled-coil motifs play essential roles in protein assembly and molecular recognition, and are therefore the targets of many ongoing structural and functional studies. Marked potentiation of activity of beta-lactams against methicillin-resistant Staphylococcus aureus by corilagin.

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Evidence of immune system abnormalities in adult schizophrenia has prompted examination of the human leukocyte antigen (HLA) system. Click aspartic acid as H ILIC SPE material for selective enrichment of N-linked glycopeptides. Totally thoracoscopic repair of atrial septal defect without robotic assistance: a single-center experience. If CSD propagation is confirmed to be more effective from posterior to anterior regions in other species, this may be relevant to the pathophysiology of classical migraine because the most frequent aura symptoms (i.e., visual disturbances) originate in the occipital cortex. Membrane interaction of segment H1 (NS4B(H1)) from hepatitis C virus non-structural protein 4B. The critical D and iD units are GlcUA(2-O-sulfate)beta1-3GalNAc(6-O-sulfate) and IdoUA(2-O-sulfate)alpha1-3GalNAc(6-O-sulfate), respectively, where IdoUA represents L-iduronic acid.

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Thanks to the use of localized orbitals and the subsequent possibility of neglecting long-range interactions, the linear-scaling methods have allowed to treat large systems at ab initio level. A combination of SSR-analysis followed by the bootstrap method and database survey considering the botanical classification and other data (origin, growth habit and donor) available is recommended in order to determine duplicates. Both cardiomyocyte-restricted proteasome functional enhancement and pharmacological proteasome inhibition (PSMI) were shown to attenuate myocardial ischemia/reperfusion (I/R) injury. An electron microscopic study of rabbit and human myocardium provides further evidence of the existence of two distinct components of the sarcoplasmic reticulum. Patients who received bilateral corneal grafts were significantly less able socioemotionally than those with unilateral graft. Many of these residues are closely connected with a recently identified second binding site, and there appears to be cross-talk between the two sites. Each treatment can achieve hematologic improvement and enhance quality of life. Therefore, spinal cord injury may alter cardiac electrophysiology and increase the risk for ventricular arrhythmias. Although biomechanical properties of bonded dentin are important for resin restorations, no information for primary teeth has been reported.

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No skin changes were noted during treatment or during the first 6 months after radiotherapy treatment. Root hair formation involves the induction of a localized cell expansion in the lateral wall of a root epidermal cell. Lymphedema caused by chylous reflux and its treatment with lymphangiectomy. Computed tomography of the abdomen demonstrated protrusion of peritoneal contents through a large defect in the linea alba. Intracisternal des-acyl ghrelin inhibits food intake and non-nutrient gastric emptying in conscious rats. It is suggested that this regimen be employed in patients with this rare and lethal tumor. The activity was still 1.6 times normal even after a month of recovery.

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Scanning and transmission electron microscopy and light microscopy was obtained. We observed spontaneous fractures, skin fistulae, bone sequestration and active bone remodelling. Use of aygestin patient reviews smokeless tobacco (Pan masala, Zarda etc.) is on the increase in North India, especially in Uttar Pradesh, and is responsible for the large majority of these tumours. Genotyping of 618 patients was carried out using the Sequenoms MassARRAY genotyping system. The data offer guidance to rheumatologists and consultant physicians to facilitate efficient diagnostic testing. IFN-gamma-induced macrophage fungicidal activity against yeast cells was mediated by NO and was almost completely inhibited by N(G)-monomethyl-L-arginine (L-NMMA), a competitive inhibitor of NO synthesis, while N(G)-monomethyl-D-arginine (D-NMMA), an optical isomer of L-NMMA, did not show any influence. Robotic rehabilitation has been identified as a promising new solution, however, much of the existing technology in this field is focused on the more proximal joints of the upper arm.

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Nevertheless, complete clinical and electromyographical recovery occurred within 7 months. As compared with isolates, control group interneurons exhibited significantly more spines and primary branches on apical dendrites in deep tectal layers. Here, we show in Drosophila indirect flight muscles (IFMs) that the nuclear-encoded mitochondrial inner membrane fusion gene, Opa1-like, is regulated in a spatiotemporal fashion by the transcription factor/co-activator Erect wing (Ewg). Characterization of transgenic sulfonylurea-resistant flax (Linum usitatissimum). In one patient, sertindole monotherapy was not sufficient to reduce the movement effects, but combination treatment with tetrabenazine resulted in a greater reduction in extrapyrimidal symptoms. Type IV pili (T4P) are ubiquitous bacterial cell surface structures that undergo cycles of extension, adhesion, and retraction. Pre-existent rotation of the normal spine at different ages and its consequences for the scoliotic mechanism.

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Four patients showed rises of antibody titres to Candida and two to Aspergillus fumigatus. Repression of delayed hypersensitivity to conjugated serum albumin during immune paralysis induced in guinea pig by heterologous proteins. The demographic projections estimated for Morocco indicate that between 2010 and 2030, the expected annual number of hip fractures would increase about twofold. Acinar cell basal-lateral membrane-endomembrane traffic may mediate interactions with both T cells and B cells. The extreme thermal stability of proteins from hyperthermophilic organisms is widely believed to arise from an increased conformational rigidity in the native state. We myambutol set out to see whether the surface of new ruffles arises from neighbouring membrane, or whether it comes from an intracellular pool of endocytosed membrane.

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In-process measuring of the electrical shunt resistance of laser-scribed thin-film stacks by nested circular scribes. Synthetic leonourine showed uterotonic activity in vitro and in vivo, just like its naturally occurring counterpart. Environments are patchy in not only abiotic factors but also biotic ones. Two experiments, each consisting of 21 maize populations of known pedigree, were grown at three and four environments in Minnesota in 1991. Other microfilament- and microtubule-dependent processes appear normal in cyk-1 mutant embryos, indicating that cyk-1 regulates a specific subset of cytoskeletal functions. Idiopathic cranial pachymeningitis - diabetes was not the brains. Reconstructive lower urinary tract surgery in incontinent adolescents with exstrophy/epispadias complex.

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A comparison by burst testing of three types of vascular anastomosis. After induction of dependence by morphine, different concentrations of plants aerial parts extract were injected to treated groups. HMIS will incorporate a paradigm shift in health such as removing manual records and transformation of data through the complex structure of health departments in Tamilnadu. Tropical species have expanded their ranges during warm periods and either retreated during cold periods or survived in local refuges. Forty male patients admitted to an acute psychiatric unit for treatment of inhalant dependence and inhalant-induced organic mental disorder, as diagnosed by DSM-III-R, were randomly assigned to receive five weeks of treatment with carbamazepine or haloperidol in identical-appearing capsules. When the strain was provided with precursors of ethylmalonate, a small quantity of a macrolide with the mass of 6-ethylErA was produced in addition to ErA. By screening tobacco cDNA library with MCK1 as a probe, we isolated a cDNA clone NtCPK5 (accession number AY971376), which encodes a drug interaction with flonase typical calcium-dependent protein kinase. For this process to be effective, the macrophage must presumably avoid its own virus-induced death. Should diagnostic physical examination testing become more accurate, it is very possible that improved research can be accomplished, in order to establish clinical practice guidelines to help guide examination and treatment, patient management, and improve patient outcomes.

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From March 1995 to June 2002, tendons rupture and tendons defect were repaired by ultra-deep-low-temperature allogeneic tendon grafts in 96 cases, including 51 cases of flexor or extensor tendon defect of hand, 36 cases of coracoclavicular ligament rupture, 4 cases of cruciate ligament rupture, 2 cases of calcaneus tendon rupture and 3 cases of extensor tendon defect of foot. Herein, we evaluated postoperative lung cancer recurrence and the personalized postoperative surveillance periods and methods used. Therefore, a better understanding of factors that control MCT1 function may be the key to better understanding the origins and treatment of pathological lactic acidosis. Management of exstrophy of the urinary bladder by primary closure. The tissue slurry was mechanically disaggregated and separated by hytrin brand centrifugation on a Percoll density gradient. This points to a role of copper in CO binding by terminal oxidases. Dose levels of the occupational radiation exposures in Poland based on results from the accredited dosimetry service at the IFJ PAN, Krakow. Dangerous situations are created by heavy workloads, and are aggravated by sub-optimal skill-mix, poor communication and individuals making mistakes or not following accepted procedures. Employing highly purified human monocytes as a starter population, low concentrations of Il-4 (25 U/ml) and GM-CSF (3 U/ml) in combination with Dexamethasone (Dex) (0.5 microM) in serum-free medium trigger the differentiation into FDC-like cells.

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Controlling for medication, sleep improved during CPT and PE compared to MA, and treatment gains were maintained through LTFU. Site directed mutants of Noxiustoxin reveal specific interactions with potassium channels. PF-04494700, an oral inhibitor of receptor for advanced glycation end products (RAGE), in Alzheimer disease. Washtenaw Community College Alternative Dental Assistant Education Project: an update. Synthesis of 2,3-diaryltetrazole-5-thiones and theoretical studies on atomic charge distributions of 2,3-diphenyltetrazole-5-thione.

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Due to advances in medical research, more and more diseases can be cured nowadays, which largely increases the need for an easy-to-use software in calculating sample size of clinical trials with cure fractions. The development and efficacy tests for the autoclave indicator tape. Glucagon-like peptide-1 reduces the pulsatile component of testosterone secretion in healthy males. Omega 3 fatty acid status in patients with retinitis pigmentosa. We have evaluated the effects of the volume and speed of administration of local anaesthetic during peribulbar anaesthesia. She is free of disease 36 months postoperatively and is now considering in vitro fertilization using a surrogate. Muscle tension receptors in animals monitor the tension generated by muscles. Can one establish a relationship between birth rate and community development?. A case of 50 years old man with tuberculosis of scrotum is reported here that presented with non-healing ulcer on ventral surface of left hemiscrotum for the last one year.

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