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Alfacal (Calcitriol)

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Alfacal is a man-made active form of vitamin D. Most people get enough vitamin D from exposure to the sun and from fortified food products. Vitamin D helps control parathyroid hormone and the levels of certain minerals that are needed for building and keeping strong bones.

Other names for this medication:
Actical, Admax, Alfacal, Alfacip, Apcical, Arachitol, Arcium, Aristrol, Biocitral, Calasto, Calbovic, Calcibest, Calcicare, Calcikind, Calcit, Calcitriol, Caldikind, Caldix, Calfa, Calgel, Calotec, Calsure, Caltin, Caltive, Caltop, Calvical, Calzem, Devita, Duracal, Ikmag, Lctrol, Minroset, Netxod, Novadee, Nutribone, Ostonex, Ostriol, Politrol, Primacal, Qpcal, Refirm, Rockbon, Roical, Romical, Septriol, Sunmic, Vezocal, Vitalpha

Similar Products:
Lozol, Astelin, Kemadrin, Maxalt, Fosamax, Artane, Valbason, Metformin, Tiasar, Zonda, Floxatral, Cephalexin, Dibimet,

Also known as: Calcitriol


Generic Alfacal is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alfacal are intestine and bone. Generic Alfacal receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alfacal may also act on the kidney and the parathyroid glands. Generic Alfacal is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alfacal has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alfacal, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alfacal in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alfacal produces other independent beneficial effects. Alfacal is also known as Calcitriol. Generic Alfacal treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alfacal is Calcitriol. Brand name of Generic Alfacal is Alfacal.


This section provides information on the proper use of a number of products that contain vitamin d and related compounds. It may not be specific to Alfacal. Please read with care.

For use as a dietary supplement:

Do not take more than the recommended daily amount. Vitamin D is stored in the body, and taking too much over a period of time can cause poisoning and even death.

If you have any questions about this, check with your health care professional.

For individuals taking the oral liquid form of this dietary supplement:

This preparation should be taken by mouth even though it comes in a dropper bottle. This dietary supplement may be dropped directly into the mouth or mixed with cereal, fruit juice, or other food.

While you are taking alfacalcidol, calcifediol, calcitriol, dihydrotachysterol, doxercalciferol or paricalcitol , your health care professional may want you to follow a special diet or take a calcium supplement. Be sure to follow instructions carefully. If you are already taking a calcium supplement or any medicine containing calcium, make sure your health care professional knows.

The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For alfacalcidol To treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 1 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 3 mcg a day. For parenteral dosage form (injection): Adults and teenagers—At first, 1 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 12 mcg a week. To treat diseases in which calcium is not used properly by the body: For oral dosage form (capsules): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (drops): Adults and teenagers—At first, 0.25 microgram (mcg) a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day. For oral dosage form (solution): Adults and teenagers—At first, 0.25 mcg a day. Your doctor may change your dose if needed. However, most people will take not more than 1 mcg a day.

For calcifediol To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage form (capsules): Adults, teenagers, and children over 10 years of age—At first, 300 to 350 micrograms (mcg) a week, taken in divided doses either once a day or every other day. Your doctor may change your dose if needed. Children 2 to 10 years of age—50 mcg a day. Children up to 2 years of age—20 to 50 mcg a day. To treat diseases in which calcium is not used properly by the body or to treat bone disease in kidney patients undergoing kidney dialysis: For oral dosage forms (capsules and solution): Adults, teenagers, and children—At first, 0.25 micrograms (mcg) a day. Your doctor may change your dose if needed. For parenteral dosage forms (injection): Adults and teenagers—At first, 0.5 mcg injected into a vein three times a week. Your doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For dihydrotachysterol To treat diseases in which calcium is not used properly by the body: For oral dosage forms (capsules, solution, or tablets): Adults and teenagers—At first, 100 micrograms (mcg) to 2.5 milligrams (mg) a day. Your doctor may change your dose if needed. Children—At first, 1 to 5 mg a day. Your doctor may change your dose if needed.

For doxercalciferol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—10 micrograms (mcg) three times weekly at dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.

For ergocalciferol The amount of vitamin D to meet normal daily recommended intakes will be different for different individuals. The following information includes only the average amounts of vitamin D. To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes: For oral dosage form (capsules): For the U.S. Adults and teenagers—5 to 10 micrograms (mcg) (200 to 400 Units) per day. Pregnant and breast-feeding females—10 mcg (400 Units) per day. Children 4 to 10 years of age—10 mcg (400 Units) per day. Children birth to 3 years of age—7.5 to 10 mcg (300 to 400 Units) per day. For Canada Adults and teenagers—2.5 to 5 mcg (100 to 200 Units) per day. Pregnant and breast-feeding females—5 to 7.5 mcg (200 to 300 Units) per day. Children 7 to 10 years of age—2.5 to 5 mcg (100 to 200 Units) per day. Children 4 to 6 years of age—5 mcg (200 Units) per day. Children birth to 3 years of age—5 to 10 mcg (200 to 400 Units) per day. To treat deficiency: Adults, teenagers, and children—Treatment dose is determined by prescriber for each individual based on severity of deficiency. To treat diseases in which calcium and phosphate are not used properly by the body: Adults and teenagers—At first, 1000 to 500,000 Units a day. The doctor may change your dose if needed. Children—At first, 1000 to 200,000 Units a day. The doctor may change your dose if needed.

For paricalcitol To treat an overactive parathyroid gland in patients with kidney failure: For oral dosage form (capsules): Adults—1 to 2 micrograms (mcg) one time per day or 2 to 4 mcg three times a week (not more often than every other day). The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor. For parenteral dosage form (injection): Adults—0.04 to 0.1 micrograms (mcg) per kg no more than every other day during dialysis. The doctor may change your dose if needed. Children—Use and dose must be determined by your doctor.


If you overdose Generic Alfacal and you don't feel good you should visit your doctor or health care provider immediately.


Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Alfacal are:

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A unified biosocial theory of personality and its role in the development of anxiety states. Investigation of the simultaneous binding of CRP, RNA polymerase (RNAP) and H-NS on the pelD gene revealed that these three proteins form a nucleoprotein com-plex. A partial restriction map of the FSH-beta gene in sheep suggests that the insertion/deletion is approximately 2 kb in size and located downstream from the third exon. Defining the molecular mechanisms underpinning fetal (gamma) globin gene silencing may provide strategies for reactivation of gamma-gene expression, a major therapeutic objective in patients with beta-thalassemia and sickle cell disease (SCD). The performance and validity of the sensor are presented by comparing the measured results against the reference data acquired from an automatic hematology analyzer. The results do not suggest that these glycoproteins can be used as tumour markers.

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To explore self-rated physical and psychosocial health in a cohort of young adults with juvenile idiopathic arthritis (JIA) 18.3 years after symptom onset, make comparisons with population-based data, and illuminate possible predictors of self-rated health. The increase of VSMC migration in coculture was equivalent to the uPA-induced migration of monocultured VSMC and was blocked by addition into coculture of soluble uPAR (suPAR). Fetal crown rump length (CRL) was measured weekly in 33 singleton pregnancies that were established after in vitro fertilization, gamete intrafallopian transfer or natural intercourse in monitored infertility treatment cycles. ViaSpan group demonstrated a lower capacity to detoxify ammonia and to synthesize urea than fresh LMOs during the whole reoxygenation period which correlated with the lower mRNA levels and activities for CPSI and OTC observed for this group. bacteriovorus UKi2 grown under saprophytic and parasitic conditions indicate that development and ultrastructure are similar in both modes of growth. Abdominal CT scans were reviewed in a series of 53 patients who had abdominal pain without objective physical, radiographic, or laboratory abnormalities.

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High p300 and CBP expression are independent prognostic markers of poor overall survival for resected SCLC patients. A simple method is described for labelling cells with fluorescein and using them in artificial mixtures to assess cell separation procedures. This finding is consistent with exertion of cognitive control relative to the state of physiologic appetite stimulation. A primary role for opioid peptides as neuromodulators of postictal seizure arrest and refractoriness is now recognized, and the existence in the central nervous system (CNS) of an endogenous anticonvulsant substance activated by electroconvulsive shock (ECS) has been determined. Estimates of membrane strain in shear hemolysis of osmotically inflated near spherical red cells. Skeletal maturation of the hand and wrist in West African children. Subsequent neurolytic blockade in 31 of these patients achieved an effective denervation as assessed by the same physiological measurements. Chemopreventive properties of phytosterols and maslinic acid extracted from Coleus tuberosus in inhibiting the expression of EBV early-antigen in Raji cells.

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Isolation and properties of a novel IgG-binding protein from streptococci of serological group U. Monitoring and early detection of these risk factors and markers can lead to changes in treatment before tissue damage is too severe. Cutaneous sequelae were evaluated according to the time of healing and the quality of the scars. The use of a neutral zone technique to fabricate a more stable complete mandibular denture for a maxillofacial patient is presented. Effects of age and starting age upon side asymmetry in the arms of veteran tennis players: a cross-sectional study. A major mechanism implicated in the antiproliferative action of somatostatin involves activation of the SH2 domain-containing protein tyrosine phosphatase SHP-1.

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Influence of timing of cytotoxic drug treatment on the response of murine clonogenic spermatogonia to X-irradiation. Detection rate of guanylyl cyclase C (GCC) mRNA was determined in 1,495 LNs from 99 CRC patients. Furthermore, the time has come to consider hepatic transplantation before any irreversible renal damage has occurred in these patients. To highlight these recurring or specific characteristics, the authors gathered and studied a large part of the stamps produced in the world on the theme of transfusion and blood donation. Effects of maternal protein deprivation on the nutritional status and neutrophil function of suckling neonatal rats.

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Seventy-five implants were placed in nine jaws of seven patients. The aims of this study were: i) to examine the expression of apoptosis-related proteins along the crypt-lumen axis during 1, 2-dimethylhydrazine (DMH)-induced carcinogenesis, ii) to assess whether a diet supplemented with the soluble fiber pectin affects those parameters, in comparison to non-carcinogen-treated rats and in relation to rats fed a standard diet and treated with DMH. The CUPI needs to be validated by different cohorts of patients before it can be recommended for general use. Rosi treatment for 3 weeks restored endothelium-dependent vasorelaxation and the expression of eNOS and the adrenoceptor activation at the doses below 10-6 mole/L in ZDF rats at 19 weeks of age. In this review, we compile evidence for protein recycling in Plasmodium parasites and discuss the role of the 26S proteasome as a prospective multi-stage target for antimalarial drug discovery programs. The amplified DNA was hybridized with a pair of allele-specific oligonucleotide probes. Conservationists frequently use nest count surveys to estimate great ape population densities, yet the accuracy and precision of the resulting estimates are difficult to assess. The human immunodeficiency virus type 1 (HIV-1) trans-activator protein Tat stimulates transcription of the integrated HIV-1 genome and promotes viral replication in infected cells. We have adopted both a dominant negative approach and a method using neutralizing monoclonal antibodies in order to inactivate this receptor. To elucidate the molecular basis of the transition-state ensemble, we have carried out high-temperature molecular dynamics simulations of the unfolding process.

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Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B. This case suggested that the level of serum alpha fetoprotein might be a useful indicator after surgery. Study of the origin of nondisjunction in a family with two cases of Down syndrome using cytogenetic and molecular polymorphisms. Electrocoagulation in the treatment of recurrent malignant tumors of soft tissues. Biochemical, functional and morphological studies on dogs with different degree of cholesterolemia. The phase behavior of the CO(2)/Ls-54/H(2)O system, solvatochromic probe study, and the UV spectrum of lysozyme proved the existence of water domains in the SC CO(2) microemulsions. A keratin mutation, E337K in K6HF, was possibly causative in 3 of the 9 families studied. This study describes a very early susceptibility to measles in infants of both vaccinated women and women with naturally acquired immunity.

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Role of malic enzyme during fatty acid synthesis in the oleaginous fungus Mortierella alpina. Our results show that levels of HO activity and expression of inducible Hsp70 and the ratio of GSH/GSSG in the different brain regions examined were positively correlated with the content of peroxides. Fluorescent microscopic observation revealed that the complex was homogeneously distributed in the muscle tissue around the injected site by US irradiation without any dissociation of plasmid DNA. Extraction and quantification of paraquat in liver and hemolyzed blood. In this dose-finding study, there were no differences in fibrinolysis or clinical outcomes among the two tranexamic acid schemes and placebo. Chemotherapy does not appear to impact survival, but it is our belief that combined protocols may offer superior outcomes to single therapeutic interventions.

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Assessment of myocardial perfusion and function in victims of scorpion envenomation using gated-SPECT. In four of the 13 fetuses, the MRI diagnosis differed from that of ultrasound best time to take diflucan when taking antibiotics and ultimately proved correct. All the analyses consistently suggested that the six proteins formed a monophyletic group implying that they probably be originated from an ancestral protein form through repeated duplication events. This in vitro study was performed (1) to assess the amount of biofilm formation on a sand-blasted and acid-etched titanium fixture treated with ultrasonic scalers with metal, plastic, and carbon tips and (2) to evaluate how this treatment of titanium surfaces affects implant cleaning by brushing with dentifrice. One week later at slaughter, IGF-1 production by liver slices and IGF-1 mRNA concentrations in skeletal muscle and liver were measured. The numbers of sections showing isthmuses at each level of the root canals were recorded too. Human alpha-galactosidase A for use in enzyme therapy has previously been obtained from human sources and from recombinant clones derived from human cells, CHO cells, and insect cells. We examined the relations between sunburn and sun-related behaviour by logistic regression analysis. CS inhibited S100b-induced TGF-beta1 and fibronectin expression in mouse mesangial cells by suppressing activation of Smad2/3, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK), and oxidative stress.

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Serum levels of vascular endothelial growth factor in a haemangiosarcoma patient with a newly typed p53 gene point mutation. Adenylate cyclase activity was localized in various tissues of the early chick embryo using an sinequan 100 mg ultrastructural histochemical technique. Histologically, testosterone had no effects on growth cartilage, but did produce thinning of the bone trabeculae in males. The multidimensional analysis of asymmetries in alphabetic confusion matrices: evidence for global-to-local and local-to-global processing. Eosinophilia, in turn, is a hallmark clinical feature associated with allergic rhinitis, atopic dermatitis, sinusitis, and asthma. This study attempts to define the cellular electrophysiology of the ablation region prior to and after the elimination of fast AV node conduction.

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This in vitro study compared 5 different dowel space impression techniques using polyvinyl siloxane impression material to determine which method produced fewer voids in the dowel space impression. Copyright 2000 The Association for the Study of Animal Behaviour. Relevant literature on exenatide QW and diabetes was identified through PubMed database searches from inception until September 2013. There was inhibition of the hCG response by thymus extracts of the newly hatched chicken. We compared bactrim ds oral tablet , in a prospective, randomized clinical trial, the subjective and objective outcomes after primary anal sphincter overlap or approximation repair of third-degree obstetric tears.

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New strains of laboratory animals in the collection stock of the Academy of Medical Sciences of the USSR. Perioperative acute myocardial infarction after valve replacement. The carotenoid-continuum: carotenoid-based plumage ranges from conspicuous to cryptic and back again. Ambulatory treatment for falciparum malaria must be considered only if a number of conditions are met, making potential complications most unlikely. The nondislodgeable endoprosthesis has been inserted into 11 patients with biliary obstructions due to malignant strictures.

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This approach can be performed as safely in older patients as it is in younger patients, with similar incidence of mortality. Fibromuscular dysplasia is suspected to be the underlying arterial disease, but other unknown arteriopathies cannot be excluded. This article explores key concepts involved in caring for incarcerated individuals, including their characteristics and assumptions others make about them. Primary study on repair of mandibular defect using free fibular composite flap. Potential benefits include avoidance of a stoma, lower morbidity, shorter hospital stay, and a lower cost of care. To compare the cellular and extracellular matrix characteristics of the annulus from control and cordarone 200 mg tabletten surgical disc specimens using electron microscopy and specialized fixation that visualizes proteoglycans.

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The results obtained showed that the activity of this membrane enzyme increased in the fractions of the cerebral cortex containing nerve endings and microsomes (Mic(20) and Mic(100)) isolated during the seizure, but not in the post-seizure period. Cardiogenic motion of right lung parenchyma in anesthetized intact dogs. The underlying cause of the visible changes of the appendiceal area remains unclear, but there are several presumptions. Our study indicates that a radiologically granular or nodular appearance of the esophageal mucosa often indicates reflux esophagitis and less commonly identifies diffuse lesions of variable origin. The prevalence of allergic diseases has increased particularly over the past 30-40 years. This study was to evaluate the relationship of 25(OH)D3 levels with anticonvulsant use and other possible factors in epileptic children and adolescents. The effect of swelling and cationic character on gene transfection by pH-sensitive nanocarriers. Trends and outcomes of total and partial nephrectomy in children: a statewide analysis.

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A new focus of cutaneous leishmaniasis caused by Leishmania tropica. Evolution converted the original simple atonal-dependent neurosensory cell formation program of diploblasts into the derived developmental program of vertebrates that generates two neurosensory cell types prometrium vaginal dosing , the sensory neuron and the sensory hair cell. In this article, the current understanding of interactions of the stress and immune systems and the physiologic and pathophysiologic implications of these interactions in human health and disease are reviewed. Unified framework for correlations in terms of local quantum observables. Novel thermoablative techniques provide the surgeon with an exciting opportunity to participate actively in the management of unresectable HCC. Also, the electromyographic response from the same muscle was recorded when the facial nerve was electrically stimulated at a location near the brainstem.

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Minimal sclerosant concentration of hypertonic saline and its relationship to vessel diameter. Therefore, additional studies, such as a diethylenetriaminopentaacetate-T-99m scintigram and a preoperative kidney biopsy under sonographic control, are suggested. Computerized tomography (CT) of the pelvis showed abnormalities consistent with radiation scarring and extravesical tumor. The targeted users of this system are research clinician s interested in finding patient cohorts for research studies. We therefore specifically addressed the possible association between MICA 5.1 homozygosity and skin cancer, as these individuals are expected to be at the highest risk for skin cancer if the MICA gene plays a role in skin carcinogenesis. Nevertheless, management of the local urinary condition and removal of the local underlying disease are the most effective approaches to treating urinary biofilm infection. A marked increase of spatial resolution over confocal microscopy becomes manifested in 4Pi-confocal three-dimensional (3D) data stacks of dual-labeled objects. Plasminogen activator, secreted sumycin suspension tetracycline drug category by metastatic tumor cells, was strongly inhibited in buffer or tissue culture medium containing physiological concentrations of NaCl.

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