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Alfacalcirol (Calcitriol)

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Alfacalcirol is a synthetic physiologically-active analog of vitamin D, specifically the vitamin D3 form. Alfacalcirol regulates calcium in vivo by promoting absorption in the intestine, reabsorption in the kidneys, and, along with parathyroid hormone, regulation of bone growth. Alfacalcirol receptor-binding protein appears to exist in the mucosa of human intestine.

Other names for this medication:
Actical, Admax, Alfacal, Alfacalcirol, Apcical, Arachitol, Arcium, Aristrol, Biocal, Bonestat, Bonetuf, Calcibest, Calcicare, Calcigra, Calcikind, Calcimet, Calcit, Calcitriol, Caldikind, Calfa, Calosto, Calotec, Calsonic, Calsure, Caltin, Caltive, Calzem, Coecoral, Devita, Koncal, Laretol, Minroset, Netxod, Nutribone, Ostriol, Politrol, Rical, Ritoca, Roical, Rolsical, Septriol, Sorvate, Tobalt, Vitalpha, Zaxial

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Also known as: Calcitriol


Generic Alfacalcirol is a synthetic vitamin D analog which is active in the regulation of the absorption of calcium from the gastrointestinal tract and its utilization in the body. The two known sites of action of Generic Alfacalcirol are intestine and bone. Generic Alfacalcirol receptor-binding protein appears to exist in the mucosa of human intestine. Additional evidence suggests that Generic Alfacalcirol may also act on the kidney and the parathyroid glands. Generic Alfacalcirol is the most active known form of vitamin D3 in stimulating intestinal calcium transport. In acutely uremic rats Generic Alfacalcirol has been shown to stimulate intestinal calcium absorption. The kidneys of uremic patients cannot adequately synthesize Generic Alfacalcirol, the active hormone formed from precursor vitamin D. Resultant hypocalcemia and secondary hyperparathyroidism are a major cause of the metabolic bone disease of renal failure. However, other bone-toxic substances which accumulate in uremia (eg, aluminum) may also contribute. The beneficial effect of Generic Alfacalcirol in renal osteodystrophy appears to result from correction of hypocalcemia and secondary hyperparathyroidism. It is uncertain whether Generic Alfacalcirol produces other independent beneficial effects. Alfacalcirol is also known as Calcitriol. Generic Alfacalcirol treatment is not associated with an accelerated rate of renal function deterioration. No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. Generic name of Generic Alfacalcirol is Calcitriol. Brand name of Generic Alfacalcirol is Alfacalcirol.


Generic Alfacalcirol is available in capsules (0.25 mcg) and liquid form. Capsules must be swallowed whole. Do not crush or chew them. If you are prescribed the liquid form, use as directed. Follow dosing instructions closely. Do not take this medication with mineral oil or magnesium containing antacids which may reduce its effects. Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and fresh-water fish. Vitamin D is also obtained from periodic exposure to the sun. It is important to maintain a well-balanced diet while taking this medication. Calcium supplements may be recommended in addition to this medication. If you want to achieve most effective results do not stop taking Generic Alfacalcirol suddenly.


If you overdose Generic Alfacalcirol and you don't feel good you should visit your doctor or health care provider immediately.


Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Side effects

The most common side effects associated with Alfacalcirol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


It is especially important that you receive the right amounts of vitamins so that your baby will also get the vitamins needed to grow properly. Infants who are totally breast-fed and have little exposure to the sun may require vitamin D supplementation. However, taking large amounts of a dietary supplement while breast-feeding may be harmful to the mother and/or baby and should be avoided.

Only small amounts of alfacalcidol, calcifediol, calcitriol, or dihydrotachysterol pass into breast milk and these amounts have not been reported to cause problems in nursing babies.

It is not known whether doxercalciferol or paricalcitol passes into breast milk. Be sure you have discussed the risks and benefits of the supplement with your doctor.

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We report this case in detail together with another, similar case which we had encountered previously. However, the central, cysteine-rich region contains all the information required for both DNA binding and trans-activation. IR and SEM analysis of the outer erosion and inner intact zone revealed that the outer zone degraded more rapidly than the inner zone. Interpretation of abnormal serum enzyme activities in occult diseases. Blood flow of peripheral nerve effects of dissection, stretching and compression. Our results showed that simple polypectomy and more invasive surgical procedures led to subjective improvement in symptoms of menorrhagia and metrorrhagia and a high satisfaction rate in women with endometrial polyps. Experiences with the posterior pharyngeal flap for correction of velopharyngeal insufficiency. Dynamic topography of the brainstem potentials of visual sensorial and motor functions. Proteomic patterns associated with EC were identified by Biomarker Patterns Software. The specific interest of these scales is more in the symptomatic intensity than in the diagnosis.

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The cellular content of this protein is also increased in hypothyroid rats. An unusual treatment for a rare dilemma (oesophageal foreign body). The irradiations were carried out in aqueous, N2O-saturated solutions in the absence and presence of oxygen and at different concentrations of glutathione (GSH). The potential role of steroid receptors status in uterine cancer tissue is discussed. Mechanisms underlying contraction and relaxation induced by nerve stimulation in monkey uterine arteries. Polarographic determination of berberine in the presence of H(2)O(2) in medicinal plants.

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A very important issue is the development of wasteless methods of biodiesel production. Initial clinical experience with electrocardiographically gated nuclear magnetic resonance imaging (0.35 tesla) in patients has clearly defined internal cardiac anatomy without the use of contrast media. Applications of different types of gas-permeable contact lenses in keratoconus and their visual results. Next we studied the effect of this inhibition on cell viability. A DART molecule specific for the mouse ortholog of CD32B and CD79B was also constructed and tested for its ability to inhibit B cell proliferation in vitro and to control disease severity in a collagen-induced arthritis (CIA) model. After obtaining baseline values, MAP was raised by an infusion of norepinephrine to reach an MAP increase of at least 10 mm Hg. Retrograde labelling of thalamic neurons was present in the dorsolateral thalamus, rostrolateral part (DLAlr) and dorsolateral thalamus, lateral part (DLL).

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An alternative method of assessment of HLA incompatibilities in kidney grafts. Previous studies indicate that the interpretation of trial results can be distorted by authors of published reports. This article provides a conceptual framework for the periprocedural management of antithrombotic therapy, with a focus on the procedures that hospitalists are most likely to perform and the pharmacology of the common and newer antithrombotic medications. Cooperation of obstetrician and pediatrician in the treatment of morbus haemolyticus neonatorum. Recruitment through tandem running in the ant Bothroponera tresserinoda.

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With hairplates occluded, all locusts exhibited downwind turning tendencies. The data presented in this report are consistent with the conclusion that losulazine reduced arterial blood pressure in nonhuman primates via depletion of norepinephrine from postganglionic adrenergic neurons. Case 2 was a 51-y-old female who consumed 20 pieces of lower stem and root of Ji Mu Ju stewed with meat and 100 ml of wine to treat chronic contact dermatitis. Methods of positioning fish for surgery or other procedures out of water. Over the past quarter century, supramolecular chemistry has grown into a major field and has fueled numerous developments at the interfaces with biology and physics. Our study reveals evolutionarily conserved genes that modulate hypoxia tolerance. Topical administration of lidocaine has been suggested to have beneficial clinical effects in patients with active ulcerative colitis, but the mechanism of action, if any, remains obscure.

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Immunological aspects of secondary progressive multiple sclerosis. A comparison was made between the effectiveness of sodium picosulphate and that of standardised senna in a group of 50 long-stay geriatric patients. Little is known regarding the potential alterations in these patterns in patients with chronic obstructive pulmonary disease (COPD), yet the impact of swallowing impairment and aspiration on the health outcomes of patients with COPD may be significant. The approach consisted of a linear skin incision along the upper eyelid crease extending to 2 cm from the canthal angle and resection of the lateral orbital rim, lateral orbital wall, and infiltrated sphenoid wing. We conclude that hepatic extraction efficiency for non-bile-salt cholephilic organic anions depends on a combination of ligand hydrophilic/hydrophobic balance and the availability of the unbound ligand for uptake. Cisplatin (1-10 micrograms/ml) had an antimitotic activity and modified the DNA content in ELT cells. This study demonstrates the value of using quantitative proteomic techniques to explore the effect of chemical exposure on the rat serum proteome and its potential for unraveling cellular targets altered by BPA and genistein involved in carcinogenesis.

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The N-terminal globular domain of the laminin alpha chains has an important role for biological activities through interactions with cell surface receptors. This chapter describes the construction of ligand-responsive miRNAs that undergo reduced processing and subsequent gene silencing when bound by the recognized ligand. The dose rate at which the DNR shows a minimum value, if selected as the treatment dose rate, gives an optimized dose distribution. The stimulants produced a dose-related decrease in upper airway resistance. Tea and coffee consumption and risk of esophageal cancer: the European prospective investigation into cancer and nutrition study. Consolidation of passive avoidance learning is associated with transient increases of polysialylated neurons in layer II of the rat medial temporal cortex.

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Poly- and perfluorinated organic compounds (PFCs) are ubiquitous in the Arctic environment. Proceedings: Control of prolactin biosynthesis in vitro by insulin. For fixation parameters patients with hemianopia fixated different spatial positions from controls, made more fixations which were more widely distributed and of shorter duration than controls, and spent a greater proportion of their total fixation time in the area corresponding to their blind hemifield. To evaluate the performances of two newly developed rapid serology tests for Helicobacter pylori infection. This disintegration of sequential thought is related to impaired immediate memory. old) and a control group of 12 normal readers (second-graders) were tested on a memory task with rhyming and non-rhyming items. Plain abdominal radiography on admission showed a radiopaque material in the gallbladder. The steady state transmembrane resting potential difference (V(m)) has been measured in quiescent papillary muscles. Humidity-modulated phase control and nanoscopic transport in supramolecular assemblies. The utility of a conjugate of ?-bungarotoxin and horse-radish peroxidase for the histochemical visualization of binding sites of intact axons or axonal vesicles is discussed.

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FAK constructs lacking the central catalytic domain or containing a point mutation, rendering the catalytic domain enzymatically inactive, did not provide protection from apoptosis. Acute ulceronecrosing enteritis with disseminated lenticular localization and perforative tendency. Effects of the glucocorticoid milieu on the basal and ether stress-induced prolactin (PRL) release and on the immunostaining for hypothalamic vasoactive intestinal peptide (VIP), beta-endorphin (beta-EP), dynorphin-A (DYN-A) and methionine-enkephalin (Met-ENK), were examined in separate groups of male rats. Differences in phospholipid composition between wild strains and streptomycin resistant mutants of certain enteric bacteria. Purification and characterization of heparinase from Flavobacterium heparinum.

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We screened an ethyl nitrosourea mutant mouse library for IMPase gene (Impa) mutations and identified an Impa1 T95K missense mutation. The process initiated by the experiencing of unusual or distressing signs or symptoms and completed by seeking treatment for those complaints is a complex one, involving several steps. Finally, although it is clear that gonadal hormones have dramatic permanent effects on the brain during perinatal development, even after puberty and in adulthood gonadal steroids can alter neuronal structure and, perhaps as a corollary to this, have permanent effects on reproductive function. Interocular transfer of learning in the pigeon: visuo-motor integration and separation of discriminanda and manipulanda. Additionally, in five cases of pulmonary edema, a negative gradient of colloid osmotic pressure to pulmonary capillary wedge pressure gradient was observed. In addition, soma size was significantly larger in the low-frequency portion of the anterovental cochlear nucleus in domesticated gerbils compared to wild gerbils. Recurrence of AVM after removal is rare, but patients with AVM surgery should be followed up with CT and angiography for a long period of time. However, the physiological properties of the avian basal ganglia have not been studied, and these properties are critical for inferring functional similarity.

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Within a given species there is a marked tendency for groups of chromosomes to accumulate heterochromatin with similar fluorescence behaviour at similar sites. eIF-4B binds to m7GTP-Sepharose, whereas the stimulatory factor does not. In contrast, the mutation P48S affected neither gp120 binding, nor class II MHC binding, nor T-cell activation. However, this treatment approach has proven to be ineffective in preventing hepatic metastases, and thus has had little effect upon overall survival. Relationship between carotid intima-media thickness, atherosclerosis risk factors and angiographic findings in patients with coronary artery disease. The researches on scaffold for tissue engineered meniscus is an essential element. Our investigation indicates that both APACHE II and MPM are good predictors of hospital outcome in our population, but the level of intensive care services received before conventional ICU admission modifies accuracy of predictive models. Isthmic salpingostomy does not require a separate procedure in order to retain arterial blood supply to the oviduct.

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This slowing could be reduced and the burst substantially prolonged by chloramine-T (CT), an agent that reduces sodium channel inactivation in several preparations. Chronic administration of astemizole and oxatomide caused only transient suppression of the response. Experimental and clinical use of antilymphocytic serum in kidney transplantation. Impact of plaque burden on subsequent intimal proliferation and remodeling of the stented coronary arteries following intracoronary beta-radiation therapy. Identification of two GDP-6-deoxy-D-lyxo-4-hexulose reductases synthesizing GDP-D-rhamnose in Aneurinibacillus thermoaerophilus L420-91T. This study suggests that virological and immunological responses are comparable in asymptomatic therapy-naive HIV-1-infected subjects with CD4 cell counts above or below 500 x 10(6)/l.

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This success in bringing HAT under control led to its inclusion in the WHO Roadmap for eradication, elimination and control of neglected tropical diseases, with a target set to eliminate the disease as a public health problem by 2020. Up to the time of this writing, there had been no clinical recurrence. One operative strategy to reduce these predispositions is presented. However, evidence that directly links these changes to differences in the para que sirve neurontin 800 mg ecological performance of particular genotypes is scarce. Use of an islanded fasciocutaneous flap in the lower limb following distraction callotasis. It is particularly important that primary health personnel correctly diagnose a presenting condition and provide care as early as possible. Neither malalignment nor damage to the neurovascular structures was observed. Carbohydrate composition of non-collagen proteins and the degree of mineralization of the bone tissue, as well as utilization of carbohydrates and mineral substances from the egg shell were investigated at various stages of embryonic development. In addition to traditional risk factors, several uremia-related risk factors such as inflammation, oxidative stress, endothelial dysfunction, coronary artery calcification, hyperhomocysteinemia, and immunosuppressants have been associated with accelerated atherosclerosis.

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The SENIC index had a somewhat better ability than the NNIS index only when the number of discharge diagnoses (not truly a predictive factor) were involved in the calculation of the SENIC index. The results revealed that CFU-mix, BFU-E, and CFU-E had begun to express H-2K antigen as early as day 16 of gestation, and antigens increased sequentially thereafter. Medetomidine at doses of 25 and 50 micrograms/kg induced moderate to deep sedation, but only with the highest medetomidine dose tested, 100 micrograms/kg, was the immobilization complete. Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. These findings, although still not completely clarified, constitute a significant opportunity for preventive intervention. Altogether, our results suggest that methylation-independent DNA binding allows ROS1 to perform a highly redundant search for efficient excision of a nondamaged, correctly paired base such as 5-meC in long stretches of DNA. Improving tofranil 25 mg tab price in pakistan nutrition components in medical and dental school curriculums. Estrogen levels reduced to the normal level shortly after the operation.

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During social interaction, verbal language as well as nonverbal behavior is exchanged between speakers and listeners. Long-term outcome and prognostic indicators in the hemolytic-uremic syndrome. New pediatric splint for fixation of the upper or lower extremities during venous infusion therapy. Domains B (nucleotides 19 to 40) and C (nucleotides 41 to 51) contain accessory sequences that significantly increase the activity of the minimal origin. In most cases, the prostatic carcinoma (PCA) is a hormone-dependent malignant tumor. A patient with cholestatic hepatitis due to amiodarone treatment is presented below and a review of the hepatotoxicity of amiodarone is given.

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Thus, E(2) was able to induce AKT (Ser473) and BAD (Ser112) phosphorylation in C2C12 cells in the absence or in the presence of H(2)O(2) but not when the cultures were incubated with H(2)O(2) and MAPK inhibitors. Interlocking disulfides in circular proteins: toward efficient oxidative folding of cyclotides. The data show that the apoptotic effects of proinflammatory stimuli mainly were due to the expression of inducible NO synthase. The late effects of treatment with extracorporeal membrane oxygenation (ECMO) in nonneonatal pediatric cymbalta type of drug patients remain unclear. Extension of the lesion may have ophtalmological implications, with the possibility of causing visual impairment. The 8D7 antigen is expressed differentially on density-defined macrophage subpopulations isolated from RA synovial tissue and is expressed more strongly on macrophages that are nonangiogenic than those that are angiogenic. Induced pluripotent stem cells as a model for telomeric abnormalities in ICF type I syndrome. The indication for surgery was based on two criteria: risk of a functional impairment or risk of morphological sequela.

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Response to treatment was monitored with serum bile acid imdur 40 mg concentrations and computer-assisted technetium Tc 99m iprofenin (Pipida) scintigraphy. One hundred and thirty specimens of esophageal cancer tissue were collected at surgery and analyzed in a telomeric repeat amplification protocol (TRAP) assay. A multiresonancelike behavior of the variance and SNR as functions of the memory exponent is observed and a connection between this effect and the memory-induced enhancement of energetic stability is established. PET with FDG turned out to have a poor sensitivity and specificity in revealing occult metastasis and has no role for the evaluation of otherwise clinically N0 necks. Discriminating between coherent and incoherent frequency modulation of complex tones.

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Examples are given for the use of these tools with clients and with family members. Pathophysiologic relevance of neurohumoral measurements in chronic heart failure. Mucosal adsorption and absorption of vitamin B12 in the intestine of the rat. Individual satisfaction with the knee was measured by having participants complete the Flandry (also known as Hughston Clinic) self-assessment questionnaire. Individuals with systemic mast cell disease (SMCD) may develop various hematologic abnormalities, including cytopenias, myeloproliferative or myelodysplastic syndromes, lymphoproliferative syndromes, and primary or secondary leukemias. Further research is needed into effective long-term treatment for ST use among addiction or psychiatric patients. Effect of vascular pathology on the clinical picture of schizophrenia. All cytoplasmic spaces contained mRNA except where scattered myofibrils and centrally located nuclei were found. Catheterisation performed 4 years and 7 months after the operation showed reopening of a left superior caval vein draining into the pulmonary venous atrium.

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The findings provide a framework for future investigations of decision-making in maladaptive behaviors. A new method, using the digital picture subtraction, is presented. High-level fluoroscopic boost options that exceed conventional exposure limits are available as a means of reducing quantum mottle during angiography. A new photoaffinity probe, 5-(1-hydroxy-4-azidophenylazo)-1,2,3-benzenetricarboxylic acid, was synthesized and characterized. Spontaneous mutations occurring in amphibians Ambystoma mexicanum Shaw, Pleurodeles waltlii Michah, and Xenopus laevis Daudin.

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(2) To determine the genetic mutation in relation to clarithromycin resistance. This relation and other ultrastructural differences suggest that physiological properties of synapses are influenced by morphological features. Acetylcholine release from synaptosomes of submucosal nerves of guinea-pig colon was significantly reduced by zaldaride. A remarkable feature of prions is that infectious particles composed of the same prion protein can give rise to different phenotypes. Effective interactions and volume energies in charged colloids: linear response theory. Respiratory failure may require long term oxygen and non invasive mechanical ventilation. In a multiple choice recognition test and a yes-no recognition test, false recognition to antonyms of targets occurred more often in the Memory group than in the Impression group. The main significant causes of incidence rate of digestive apparatus pathology and the ways of their elimination are discussed.

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