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Allerdain (Desloratadine)

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Allerdain is loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. Allerdain is used to provide symptomatic relieve of allergic symptoms. The major metabolite of loratidine, Allerdain is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness. It has a role as a H1-receptor antagonist, an anti-allergic agent and a cholinergic antagonist.

Other names for this medication:
Alerdain, Alerta, Allerdain, Allerde, Allerede, Allergesic, Antialer, Biomon, Dazit, Delorta, Descare, Desent, Deslor, Desloranid, Desloratadine, Desloriv, Desnova, Dilora, Lorday, Loreta, Nelora, Neoloridin, Nucope, Otrivin, Reditabs, Rodera, Tastylora, Veromon

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Also known as: Desloratadine


Cough/cold combinations are used mainly to relieve the cough due to colds, influenza, or hay fever. They are not to be used for the chronic cough that occurs with smoking, asthma, or emphysema or when there is an unusually large amount of mucus or phlegm (pronounced flem) with the cough.

Cough/cold combination products contain more than one ingredient. For example, some products may contain an antihistamine, a decongestant, and an analgesic, in addition to a medicine for coughing. If you are treating yourself, it is important to select a product that is best for your symptoms. Also, in general, it is best to buy a product that includes only those medicines you really need. If you have questions about which product to buy, check with your pharmacist.

Since different products contain ingredients that will have different precautions and side effects, it is important that you know the ingredients of the medicine you are taking. The different kinds of ingredients that may be found in cough/cold combinations include:

Antihistamines—Antihistamines are used to relieve or prevent the symptoms of hay fever and other types of allergy. They also help relieve some symptoms of the common cold, such as sneezing and runny nose. They work by preventing the effects of a substance called histamine, which is produced by the body. Some examples of antihistamines contained in these combinations are:

Bromodiphenhydramine Brompheniramine Carbinoxamine Chlorpheniramine Dexchlorpheniramine Diphenhydramine Doxylamine Phenindamine Pheniramine Phenyltoloxamine Pyrilamine Promethazine Triprolidine

Decongestants—Decongestants produce a narrowing of blood vessels. This leads to clearing of nasal congestion. However, this effect may also increase blood pressure in patients who have high blood pressure. These include:

Ephedrine Phenylephrine Pseudoephedrine

Antitussives—Antitussives help relieve coughing and are some contain a narcotic. These antitussives act directly on the cough center in the brain. Narcotics may become habit-forming, causing mental or physical dependence, if used for a long time. Physical dependence may lead to withdrawal side effects when you stop taking the medicine.

Narcotic antitussives Codeine Dihydrocodeine Hydrocodone Hydromorphone

Non-narcotic antitussives Carbetapentane Caramiphen Dextromethorphan

Expectorants—Expectorants work by loosening the mucus or phlegm in the lungs. The main expectorant used in cough and cold medicines is guaifenesin. Other ingredients added as expectorants (for example, ammonium chloride, calcium iodide, iodinated glycerol, ipecac, potassium guaiacolsulfonate, potassium iodide, and sodium citrate) have not been proven to be effective. In general, the best thing you can do to loosen mucus or phlegm is to drink plenty of water.

Analgesics—Analgesics are used in these combination medicines to help relieve the aches and pain that may occur with the common cold. These include:

Acetaminophen Aspirin Other salicylates such as salicylamide and sodium salicylate

The use of too much acetaminophen and salicylates at the same time may cause kidney damage or cancer of the kidney or urinary bladder. This may occur if large amounts of both medicines are taken together for a long time. However, taking the recommended amounts of combination medicines that contain both acetaminophen and a salicylate for short periods of time has not been shown to cause these unwanted effects.

Anticholinergics—Anticholinergics, such as homatropine may help produce a drying effect in the nose and chest.

These cough and cold combinations are available both over-the-counter (OTC) and with your doctor's prescription.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .


This section provides information on the proper use of a number of products that contain cough and cold combinations. It may not be specific to Allerdain-D. Please read with care.

To help loosen mucus or phlegm in the lungs, drink a glass of water after each dose of this medicine, unless otherwise directed by your doctor.

Take this medicine only as directed. Do not take more of it and do not take it more often than recommended on the label, unless otherwise directed by your doctor. To do so may increase the chance of side effects.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

For patients taking the extended-release capsule or tablet form of this medicine:

Swallow the capsule or tablet whole. Do not crush, break, or chew before swallowing. If the capsule is too large to swallow, you may mix the contents of the capsule with applesauce, jelly, honey, or syrup and swallow without chewing.

For patients taking the extended-release oral solution or oral suspension form of this medicine:

Do not dilute with fluids or mix with other drugs.

For patients taking a combination medicine containing an antihistamine and/or aspirin or other salicylate:

Take with food or a glass of water or milk to lessen stomach irritation, if necessary.

If a combination medicine containing aspirin has a strong vinegar-like odor, do not use it. This odor means the medicine is breaking down. If you have any questions about this, check with your pharmacist.


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose may cause anxiety, trouble sleeping, headache, vomiting, thirst, muscle weakness, fast or pounding heartbeats, hallucinations, shallow breathing, or a seizure.


Store at room temperature 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Allerdain are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Allerdain-D 24 Hour if you are allergic to desloratadine, loratadine (Claritin), or pseudoephedrine, or if you have:

narrow-angle glaucoma; severe coronary artery disease (clogged arteries); uncontrolled high blood pressure; or bladder obstruction or other urination problems.

Do not use Allerdain-D 24 Hour if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have ever had:

kidney disease; glaucoma; heart disease or high blood pressure; a seizure (in you or a family member); diabetes; thyroid disorder; or an enlarged prostate.

Allerdain-D 24 Hour should not be given to a child younger than 12 years old.

It is not known whether desloratadine and pseudoephedrine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breast feed while using Allerdain-D 24 Hour.

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Proximate control of diel vertical migration in Phyllosoma larvae of the Caribbean spiny lobster Panulirus argus. The role of agger nasi air cells in revision endoscopic sinus surgery. The toxicity of herbicides to non-target aquatic plants and algae: assessment of predictive factors and hazard. The scores of F, K, Hs, D, Hy, Pd, Pa, Pt and Si scales in the patients were significantly higher than those in normal controls. The stability of attractor ruin in the model is investigated by analyzing the residence time distribution of orbits at attractor ruins. Here we demonstrate that MLK2 activates SAPK kinase-1 (SKK1)/MAPK kinase 4 (MKK4) and SKK4/MKK7, the two known direct activators of SAPK1/JNK (both in transfection studies and in vitro).

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In the former group, the lesions were found mostly at C5-6 and C6-7 levels, while in the latter group involvement of C6-7 was frequently observed. A lymphocyte cDNA library of normal human was constructed in order to obtain specific gene and prepare lymphocyte gene chips to detect the relative genes between psychiatric diseases and immunity. Our results demonstrate that this individual retains a remarkable capacity for higher cognition, engaging in the reasoning task and deducing logical can you drink alcohol while on bactrim antibiotics answers. Hypocretin and its emerging role as a target for treatment of sleep disorders. SEME: a fast mapper of Illumina sequencing reads with statistical evaluation.

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By precisely regulating the composition of its cell surface and secreted polysaccharides, C. Measures included acoustic startle response, US expectancy, blood glucose levels, and arousal ratings. Phosphorylated LIM kinase 2 and cofilin, related to actin bundling and integrin clustering, were dephosphorylated (activated) by Y-27632. There are two routes of laparoscopic access to the adrenal gland: transperitoneal and retroperitoneal. The association between nocturia and nocturnal polyuria in clinical and epidemiological studies: a systematic review and meta-analyses. Sixteen of these active chemical species were benzyltriphenylphosphonium flomax capsule side effects salts. Ribosomes are large complexes of RNA and protein that perform the essential task of protein synthesis in the cell. Such understanding is prerequisite if we are to account for neural function in cellular terms.

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To review the published experience of pharmacokinetic (PK) parameters of micafungin in patients requiring some type of extrarenal depuration procedures during their stay in the ICU. (Myxozoa, Myxosporea, Myxobolidae), a parasite of the Amazonian teleost fish Semaprochilodus insignis (Osteichthyes, Prochilodontidae). Is there a cost to poor communication in cancer care?: a critical review of the literature. In particular, we will be focusing on ESCs as a promising cell source for cartilage regeneration, the various strategies and approaches employed in chondrogenic differentiation and tissue engineering, the associated outcomes from animal studies, and the challenges that need to be overcome before clinical application is possible. A method for implementing such an interface between dissimilar qubits is quantum teleportation. Subsequent primary malignancy was revealed in 1.8 per cent of 2, 689 cases with cervical and in 1.7 per cent of 773 cases with corpus carcinoma. The patients were evaluated urodynamically at regular intervals and 50 per cent were subjected to external sphincterotomy, after which they were compared for the presence of bacteriuria and upper urinary tract changes.

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